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    Jcad junctional cadherin 5 associated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498764, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Jcadprovided by RGD
    Official Full Name
    junctional cadherin 5 associatedprovided by RGD
    Primary source
    RGD:1562037
    See related
    Ensembl:ENSRNOG00000027938 AllianceGenome:RGD:1562037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562037
    Summary
    Predicted to be involved in several processes, including positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; positive regulation of cell migration involved in sprouting angiogenesis; and positive regulation of signal transduction. Predicted to be located in cell-cell junction and perinuclear region of cytoplasm. Predicted to be active in adherens junction and ruffle membrane. Orthologous to human JCAD (junctional cadherin 5 associated). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 226.5), Heart (RPKM 139.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Jcad in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (57784634..57826213, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (53089382..53130996, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (55667754..55709738, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556228 Neighboring gene uncharacterized LOC120097795 Neighboring gene uncharacterized LOC102557539 Neighboring gene uncharacterized LOC108348576 Neighboring gene uncharacterized LOC120097757

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo. Hara T, et al. Arterioscler Thromb Vasc Biol, 2017 Sep. PMID 28705794
    2. A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions. Akashi M, et al. Biochem Biophys Res Commun, 2011 Sep 23. PMID 21884682
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    junctional cadherin 5-associated protein
    Names
    junctional protein associated with coronary artery disease

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427709.1 → NP_001414638.1  junctional cadherin 5-associated protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6K9F8, F1M6T3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      57784634..57826213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096446.2 → XP_038952374.1  junctional cadherin 5-associated protein isoform X1

      UniProtKB/TrEMBL
      A6K9F8, F1M6T3
      Related
      ENSRNOP00000035031.5
      Conserved Domains (1) summary
      pfam15351
      Location:1 → 1320
      JCAD; Junctional protein associated with coronary artery disease

    2. XM_039096447.2 → XP_038952375.1  junctional cadherin 5-associated protein isoform X1

      UniProtKB/TrEMBL
      A6K9F8, F1M6T3
      Conserved Domains (1) summary
      pfam15351
      Location:1 → 1320
      JCAD; Junctional protein associated with coronary artery disease

    3. XM_039096448.2 → XP_038952376.1  junctional cadherin 5-associated protein isoform X1

      UniProtKB/TrEMBL
      A6K9F8, F1M6T3
      Conserved Domains (1) summary
      pfam15351
      Location:1 → 1320
      JCAD; Junctional protein associated with coronary artery disease

    4. XM_008771790.4 → XP_008770012.2  junctional cadherin 5-associated protein isoform X2

      Conserved Domains (1) summary
      pfam15351
      Location:1 → 1182
      JCAD; Junctional protein associated with coronary artery disease

    5. XM_008771786.4 → XP_008770008.2  junctional cadherin 5-associated protein isoform X2

      Conserved Domains (1) summary
      pfam15351
      Location:1 → 1182
      JCAD; Junctional protein associated with coronary artery disease

    6. XM_008771788.4 → XP_008770010.2  junctional cadherin 5-associated protein isoform X2

      Conserved Domains (1) summary
      pfam15351
      Location:1 → 1182
      JCAD; Junctional protein associated with coronary artery disease

    7. XM_063276696.1 → XP_063132766.1  junctional cadherin 5-associated protein isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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