Fbxw11 F-box and WD repeat domain containing 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fbxw11provided by RGD
Official Full Name: F-box and WD repeat domain containing 11provided by RGD
Primary source: RGD:1309121
See related: Ensembl:ENSRNOG00000004395 AllianceGenome:RGD:1309121
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable dynein complex binding activity; microtubule plus-end binding activity; and ubiquitin-protein transferase activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; regulation of transcription, DNA-templated; and transport along microtubule. Predicted to be located in centrosome; cytosol; and nucleus. Predicted to be part of SCF ubiquitin ligase complex and microtubule associated complex. Predicted to be active in several cellular components, including cytoplasmic microtubule; kinetochore; and neuronal cell body. Orthologous to human FBXW11 (F-box and WD repeat domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 175.6), Brain (RPKM 156.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (17737181..17834834)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (17232735..17330574)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (17542374..17640718)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH142282 (e-PCR)
- UniSTS:231529

D10RAT182 (e-PCR)
- UniSTS:120686

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dynein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule plus-end binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
contributes_to ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in brain morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in germ cell development	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule organizing center organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in retrograde axonal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: F-box/WD repeat-containing protein 11

Names: F-box and WD-40 domain protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395595.3 → NP_001382524.1 F-box/WD repeat-containing protein 11 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2JVE0

Conserved Domains (4) summary

cd00200
Location:261 → 539

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:264 → 299

7WD40; WD40 repeat [structural motif]

pfam12125
Location:99 → 137

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:141 → 188

F-box-like
NM_001395596.3 → NP_001382525.1 F-box/WD repeat-containing protein 11 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2JVE0, A0A8I6GMC9

Related

ENSRNOP00000097046.1, ENSRNOT00000118897.1

Conserved Domains (4) summary

cd00200
Location:206 → 484

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:209 → 244

7WD40; WD40 repeat [structural motif]

pfam12125
Location:44 → 82

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:86 → 133

F-box-like
NM_001414338.2 → NP_001401267.1 F-box/WD repeat-containing protein 11 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

17737181..17834834

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597240.3 → XP_017452729.1 F-box/WD repeat-containing protein 11 isoform X3

UniProtKB/TrEMBL

A0A0G2JVE0
XM_017597241.3 → XP_017452730.1 F-box/WD repeat-containing protein 11 isoform X4

UniProtKB/TrEMBL

A0A0G2JVE0

Conserved Domains (4) summary

cd00200
Location:227 → 505

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:230 → 265

7WD40; WD40 repeat [structural motif]

pfam12125
Location:65 → 103

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:107 → 154

F-box-like
XM_039085889.2 → XP_038941817.1 F-box/WD repeat-containing protein 11 isoform X1

UniProtKB/TrEMBL

A0A0G2JVE0, A0A8I6GIW9

Related

ENSRNOP00000091319.1

Conserved Domains (4) summary

cd00200
Location:264 → 542

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:267 → 302

7WD40; WD40 repeat [structural motif]

pfam12125
Location:102 → 140

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:144 → 191

F-box-like
XM_017597238.3 → XP_017452727.1 F-box/WD repeat-containing protein 11 isoform X2

UniProtKB/TrEMBL

A0A0G2JVE0
XM_039085890.2 → XP_038941818.1 F-box/WD repeat-containing protein 11 isoform X7

UniProtKB/TrEMBL

A0A8I5ZPA1, A0A8I5ZUE3

Related

ENSRNOP00000079990.1

Conserved Domains (4) summary

cd00200
Location:208 → 486

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:211 → 246

7WD40; WD40 repeat [structural motif]

pfam12125
Location:46 → 84

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:88 → 135

F-box-like
XM_017597243.3 → XP_017452732.1 F-box/WD repeat-containing protein 11 isoform X5

UniProtKB/TrEMBL

A0A0G2JVE0, D3ZXC6

Related

ENSRNOP00000059948.2
XM_017597244.3 → XP_017452733.1 F-box/WD repeat-containing protein 11 isoform X6

UniProtKB/TrEMBL

A0A0G2JVE0

Related

ENSRNOP00000069447.2

Conserved Domains (4) summary

cd00200
Location:208 → 486

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:211 → 246

7WD40; WD40 repeat [structural motif]

pfam12125
Location:46 → 84

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:88 → 135

F-box-like
XM_063268958.1 → XP_063125028.1 F-box/WD repeat-containing protein 11 isoform X8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106993.1: Suppressed sequence

Description

NM_001106993.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.