dlx2b distal-less homeobox 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dlx2bprovided by ZNC
Official Full Name: distal-less homeobox 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-18
See related: Ensembl:ENSDARG00000017174 AllianceGenome:ZFIN:ZDB-GENE-980526-18
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dlx5
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in several structures, including dental epithelium; dental mesenchyme; forebrain; parasphenoid; and splanchnocranium. Orthologous to human DLX2 (distal-less homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (30977936..30979683, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (30174005..30175752, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased expression levels of DLX5 inhibit the development of the nervous system.
Title: Increased expression levels of DLX5 inhibit the development of the nervous system.
cell transfection experiments demonstrated that Sp7 directly regulates the expression of dlx2b and bglap through Sp7-binding sites on the promoter regions of these two genes. Overall, this study provides new insight into the role of Sp7 in bone mineralization and tooth development.
Title: Sp7/osterix positively regulates dlx2b and bglap to affect tooth development and bone mineralization in zebrafish larvae.
Data indicate that retinoic acid (RA) induces the expression patterns of genes normally expressed in the posterior tooth-forming region, such as pitx2 and dlx2b.
Title: Retinoic acid expands the evolutionarily reduced dentition of zebrafish.
Zebrafish dlx2b can drive reporter expression in oral teeth of the related characiform Astyanax mexicanus.
Title: Transgenic analysis of Dlx regulation in fish tooth development reveals evolutionary retention of enhancer function despite organ loss.

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General gene information

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Markers

Z1463 (e-PCR)
- UniSTS:204655

DLX5 (e-PCR)
- UniSTS:205301

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chordate embryonic development	IEA Inferred from Electronic Annotation more info
involved_in embryo development	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein Dlx2b

Names: DLX-5; distal-less homeobox gene 2b; distal-less homeobox gene 5; distal-less homeobox protein 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131297.2 → NP_571372.1 homeobox protein Dlx2b

See identical proteins and their annotated locations for NP_571372.1

Status: PROVISIONAL

Source sequence(s)

BC134899

UniProtKB/Swiss-Prot

Q98876

UniProtKB/TrEMBL

A4IG28

Related

ENSDARP00000007080.8, ENSDART00000008469.9

Conserved Domains (2) summary

pfam00046
Location:128 → 181

Homeobox; Homeobox domain

pfam12413
Location:29 → 102

DLL_N; Homeobox protein distal-less-like N terminal