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    Zhx2 zinc fingers and homeoboxes 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314988, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Zhx2provided by RGD
    Official Full Name
    zinc fingers and homeoboxes 2provided by RGD
    Primary source
    RGD:727926
    See related
    Ensembl:ENSRNOG00000005417 AllianceGenome:RGD:727926
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and retinal bipolar neuron differentiation. Predicted to act upstream of or within mRNA catabolic process; negative regulation of neuron differentiation; and somatic stem cell population maintenance. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZHX2 (zinc fingers and homeoboxes 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 82.0), Kidney (RPKM 75.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zhx2 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (91115894..91263823)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (89226358..89374266)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (97559653..97707872)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479733 Neighboring gene uncharacterized LOC134479734 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102553568 Neighboring gene ribosomal protein L37A, pseudogene 14 Neighboring gene derlin 1 Neighboring gene TBC1 domain family, member 31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The alpha-fetoprotein promoter is the target of Afr1-mediated postnatal repression. Peyton DK, et al. Genomics, 2000 Jan 15. PMID 10673330
    2. raf regulates the postnatal repression of the mouse alpha-fetoprotein gene at the posttranscriptional level. Vacher J, et al. Mol Cell Biol, 1992 Feb. PMID 1370712, Free PMC Article
    3. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. Kawata H, et al. Biochem J, 2003 Aug 1. PMID 12741956, Free PMC Article
    4. Mouse alpha-fetoprotein gene 5' regulatory elements are required for postnatal regulation by raf and Rif. Spear BT. Mol Cell Biol, 1994 Oct. PMID 7523852, Free PMC Article
    5. The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development. Kawamura Y, et al. Biochem Biophys Res Commun, 2018 Sep 18. PMID 30146259

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinal bipolar neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc fingers and homeoboxes protein 2
    Names
    AFP regulator 1
    alpha-fetoprotein regulator 1
    regulator of AFP
    transcription factor ZHX2
    zinc finger and homeodomain protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271056.1 → NP_001257985.1  zinc fingers and homeoboxes protein 2

      See identical proteins and their annotated locations for NP_001257985.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      G3V6P3, Q80VX4
      Related
      ENSRNOP00000095233.1, ENSRNOT00000099915.1
      Conserved Domains (3) summary
      smart00389
      Location:537 → 582
      HOX; Homeodomain
      cd00086
      Location:444 → 496
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam18387
      Location:106 → 158
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      91115894..91263823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241654.5 → XP_006241716.1  zinc fingers and homeoboxes protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006241716.1

      UniProtKB/Swiss-Prot
      G3V6P3, Q80VX4
      Related
      ENSRNOP00000092484.1
      Conserved Domains (3) summary
      smart00389
      Location:537 → 582
      HOX; Homeodomain
      cd00086
      Location:444 → 496
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam18387
      Location:106 → 158
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    2. XM_017594857.3 → XP_017450346.1  zinc fingers and homeoboxes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      G3V6P3, Q80VX4
      Related
      ENSRNOP00000007326.4
      Conserved Domains (3) summary
      smart00389
      Location:537 → 582
      HOX; Homeodomain
      cd00086
      Location:444 → 496
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam18387
      Location:106 → 158
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    3. XM_063263558.1 → XP_063119628.1  zinc fingers and homeoboxes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      G3V6P3, Q80VX4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80VX4.2 GenPept UniProtKB/Swiss-Prot:Q80VX4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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