Fmod fibromodulin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fmodprovided by RGD
Official Full Name: fibromodulinprovided by RGD
Primary source: RGD:619769
See related: Ensembl:ENSRNOG00000003183 AllianceGenome:RGD:619769
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in odontogenesis; skin development; and wound healing. Located in collagen-containing extracellular matrix and extracellular region. Biomarker of tendinitis. Orthologous to human FMOD (fibromodulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 317.0), Spleen (RPKM 90.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (48045567..48056184)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (45493517..45504134)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (50874886..50885503)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transfer RNA-derived small RNA tRF-Glu-CTC attenuates neointimal formation via inhibition of fibromodulin.
Title: Transfer RNA-derived small RNA tRF-Glu-CTC attenuates neointimal formation via inhibition of fibromodulin.
Downregulation of fibromodulin attenuates inflammatory signaling and atrial fibrosis in spontaneously hypertensive rats with atrial fibrillation via inhibiting TLR4/NLRP3 signaling pathway.
Title: Downregulation of fibromodulin attenuates inflammatory signaling and atrial fibrosis in spontaneously hypertensive rats with atrial fibrillation via inhibiting TLR4/NLRP3 signaling pathway.
The fibromodulin (Fm)-transforming growth factor (TGF)-beta1 nexus plays a crucial in fetal-type scarless skin repair.
Title: Fibromodulin Is Essential for Fetal-Type Scarless Cutaneous Wound Healing.
the effects of liposomal-based delivery of fibromodulin gene were investigated in a rat Achilles tendon injury model. The positive results observed would provide a new therapeutic strategy in clinical setting in the future
Title: Enhanced Achilles tendon healing by fibromodulin gene transfer.
This study suggests that laminin and type I collagen support the function of folliculostellate cells by increasing fibromodulin protein expression in the anterior pituitary.
Title: Laminin and collagen modulate expression of the small leucine-rich proteoglycan fibromodulin in rat anterior pituitary gland.
Hepatic fibromodulin activates hepatic stellate cells and promotes collagen I deposition, which leads to liver fibrosis.
Title: Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142446 (e-PCR)
- UniSTS:231693

PMC133870P1 (e-PCR)
- UniSTS:270674

RH133402 (e-PCR)
- UniSTS:216685

D13Rat125 (e-PCR), detects polymorphism
- UniSTS:226515

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in collagen fibril organization	IEA Inferred from Electronic Annotation more info
involved_in skin development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibromodulin

Names: FM; KSPG fibromodulin; collagen-binding 59 kDa protein; keratan sulfate proteoglycan fibromodulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080698.1 → NP_542429.1 fibromodulin precursor

See identical proteins and their annotated locations for NP_542429.1

Status: PROVISIONAL

Source sequence(s)

X82152

UniProtKB/Swiss-Prot

P50609

UniProtKB/TrEMBL

A6ICA0, G3V6E7

Related

ENSRNOP00000004382.4, ENSRNOT00000004382.7

Conserved Domains (4) summary

smart00013
Location:75 → 109

LRRNT; Leucine rich repeat N-terminal domain

cd00116
Location:150 → 359

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:107 → 130

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:176 → 235

LRR_8; Leucine rich repeat