Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asap1provided by RGD
Official Full Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 1provided by RGD
Primary source: RGD:1307379
See related: Ensembl:ENSRNOG00000058733 AllianceGenome:RGD:1307379
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DEF-1; Ddef1
Summary: Predicted to enable GTPase activator activity; SH3 domain binding activity; and phospholipid binding activity. Predicted to be involved in cilium assembly; positive regulation of membrane tubulation; and positive regulation of podosome assembly. Predicted to act upstream of or within negative regulation of dendritic spine development. Predicted to be located in dendritic spine. Predicted to be active in cell projection membrane; cytosol; and podosome. Orthologous to human ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 139.2), Brain (RPKM 97.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q33

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (97675354..97982523, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (95786130..96093111, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (104670076..104951090, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ASAP1 can contribute to the dissemination of a variety of tumor types and represent a potential target for cancer therapy.
Title: ASAP1 promotes tumor cell motility and invasiveness, stimulates metastasis formation in vivo, and correlates with poor survival in colorectal cancer patients.

Submit: New GeneRIF Correction

General gene information

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Markers

D7Rat218 (e-PCR), detects polymorphism
- UniSTS:228167

AU047703 (e-PCR)
- UniSTS:110247

RH131168 (e-PCR)
- UniSTS:214451

BF406006 (e-PCR)
- UniSTS:248258

D7Rat14 (e-PCR)
- UniSTS:119019

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of dendritic spine development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane tubulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of membrane tubulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of membrane tubulation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cilium	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cilium	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cilium	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in podosome	IBA Inferred from Biological aspect of Ancestor more info
located_in podosome	IEA Inferred from Electronic Annotation more info
located_in podosome	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

Names: 130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein; 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; ARF GTPase-activating protein 1; PIP2-dependent ARF1 GAP; development and differentiation enhancing; development and differentiation-enhancing factor 1; differentiation-enhancing factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044245.2 → NP_001037710.2 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

97675354..97982523 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079180.2 → XP_038935108.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X7

UniProtKB/Swiss-Prot

Q1AAU4, Q1AAU5, Q1AAU6

Related

ENSRNOP00000071134.2

Conserved Domains (7) summary

cd07641
Location:54 → 268

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1017 → 1073

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

PHA03247
Location:727 → 979

PHA03247; large tegument protein UL36; Provisional

cd13251
Location:316 → 422

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:601 → 634

ANK; ANK repeat [structural motif]

cd08848
Location:437 → 558

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam12796
Location:605 → 677

Ank_2; Ankyrin repeats (3 copies)
XM_039079174.2 → XP_038935102.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2

UniProtKB/Swiss-Prot

Q1AAU4, Q1AAU5, Q1AAU6

Conserved Domains (7) summary

cd07641
Location:54 → 268

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1074 → 1130

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

PHA03247
Location:724 → 1036

PHA03247; large tegument protein UL36; Provisional

cd13251
Location:316 → 422

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:601 → 634

ANK; ANK repeat [structural motif]

cd08848
Location:437 → 558

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam12796
Location:605 → 677

Ank_2; Ankyrin repeats (3 copies)
XM_039079177.2 → XP_038935105.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X4

UniProtKB/Swiss-Prot

Q1AAU4, Q1AAU5, Q1AAU6

Conserved Domains (7) summary

cd07641
Location:54 → 268

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1029 → 1085

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

PHA03247
Location:739 → 991

PHA03247; large tegument protein UL36; Provisional

cd13251
Location:328 → 434

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:613 → 646

ANK; ANK repeat [structural motif]

cd08848
Location:449 → 570

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam12796
Location:617 → 689

Ank_2; Ankyrin repeats (3 copies)
XM_063263529.1 → XP_063119599.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1
XM_063263531.1 → XP_063119601.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X6
XM_039079178.2 → XP_038935106.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X5

UniProtKB/Swiss-Prot

Q1AAU4, Q1AAU5, Q1AAU6

Related

ENSRNOP00000087244.1

Conserved Domains (7) summary

cd07641
Location:34 → 248

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1054 → 1110

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

PHA03247
Location:704 → 1016

PHA03247; large tegument protein UL36; Provisional

cd13251
Location:296 → 402

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:581 → 614

ANK; ANK repeat [structural motif]

cd08848
Location:417 → 538

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam12796
Location:585 → 657

Ank_2; Ankyrin repeats (3 copies)
XM_063263530.1 → XP_063119600.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3

UniProtKB/TrEMBL

A0A8I6GFT7
XM_063263533.1 → XP_063119603.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X8

UniProtKB/TrEMBL

A0A0G2JZQ0
XM_063263535.1 → XP_063119605.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X10
XM_063263534.1 → XP_063119604.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X9
XM_063263536.1 → XP_063119606.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X11