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    Ralgdsl2 ral guanine nucleotide dissociation stimulator like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294283, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Ralgdsl2provided by RGD
    Official Full Name
    ral guanine nucleotide dissociation stimulator like 2provided by RGD
    Primary source
    RGD:1302985
    See related
    Ensembl:ENSRNOG00000000474 AllianceGenome:RGD:1302985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rgl2; Ke1.5; Rab2l
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity and small GTPase mediated signal transduction. Predicted to act upstream of or within negative regulation of cardiac muscle cell apoptotic process; positive regulation of phosphatidylinositol 3-kinase signaling; and regulation of Ral protein signal transduction. Orthologous to human RGL2 (ral guanine nucleotide dissociation stimulator like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 101.5), Thymus (RPKM 83.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ralgdsl2 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4950379..4958315, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4948495..4956774, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5458509..5466853, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 46 Neighboring gene prefoldin subunit 6 Neighboring gene TAP binding protein Neighboring gene zinc finger and BTB domain containing 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The ral exchange factor rgl2 promotes cardiomyocyte survival and inhibits cardiac fibrosis. Scotland RL, et al. PLoS One, 2013. PMID 24069211, Free PMC Article
    2. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124925

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of Ral protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ral guanine nucleotide dissociation stimulator-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212547.3 → NP_997712.1  ral guanine nucleotide dissociation stimulator-like 2

      See identical proteins and their annotated locations for NP_997712.1

      Status: VALIDATED

      Source sequence(s)
      BC107439, DY316563
      UniProtKB/TrEMBL
      A0A0U1RS29, A6JJI3, F7EQI7, Q6MGC5
      Related
      ENSRNOP00000000554.4, ENSRNOT00000000554.7
      Conserved Domains (3) summary
      cd00153
      Location:649 → 734
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00229
      Location:90 → 212
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:239 → 509
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      4950379..4958315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279023.1 → XP_063135093.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

      UniProtKB/TrEMBL
      A0A0U1RS29

    2. XM_063279024.1 → XP_063135094.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A8H6

    3. XM_063279025.1 → XP_063135095.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X3

    RNA

    1. XR_005497185.2 RNA Sequence

    2. XR_005497186.2 RNA Sequence

    3. XR_005497187.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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