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    STL1 glucose-inactivated glycerol proton symporter STL1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852149, updated on 13-Apr-2024

    Summary

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    Gene symbol
    STL1
    Gene description
    glucose-inactivated glycerol proton symporter STL1
    Primary source
    SGD:S000002944
    Locus tag
    YDR536W
    See related
    AllianceGenome:SGD:S000002944
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables solute:proton symporter activity. Involved in glycerol transport and transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1508005..1509714)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene glutathione-independent methylglyoxalase Neighboring gene Fit1p Neighboring gene phenylacrylic acid decarboxylase PAD1 Neighboring gene putative phenylacrylic acid decarboxylase FDC1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and functional studies of genes involved in transport and metabolism of glycerol in Pachysolen tannophilus. Liu X, et al. Microb Cell Fact, 2013 Mar 21. PMID 23514356, Free PMC Article
    2. Long-term model predictive control of gene expression at the population and single-cell levels. Uhlendorf J, et al. Proc Natl Acad Sci U S A, 2012 Aug 28. PMID 22893687, Free PMC Article
    3. Saccharomyces cerevisiae glycerol/H+ symporter Stl1p is essential for cold/near-freeze and freeze stress adaptation. A simple recipe with high biotechnological potential is given. Tulha J, et al. Microb Cell Fact, 2010 Nov 3. PMID 21047428, Free PMC Article
    4. Glucose repression over Saccharomyces cerevisiae glycerol/H+ symporter gene STL1 is overcome by high temperature. Ferreira C, et al. FEBS Lett, 2007 May 1. PMID 17434487
    5. A member of the sugar transporter family, Stl1p is the glycerol/H+ symporter in Saccharomyces cerevisiae. Ferreira C, et al. Mol Biol Cell, 2005 Apr. PMID 15703210, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The DNA-binding domain of Hot1 recognizes sequence 5'-GGGACAAA-3' located in the promoter of gene STL1.
      Title: The C-terminal region of the Hot1 transcription factor binds GGGACAAA-related sequences in the promoter of its target genes.
    2. results show the function of Stl1p and Fps1p transporters contributes to cell's ability to survive during transfer into state of anhydrobiosis; deletion of FPS1 decreases cell's tolerance of hyperosmotic stress; deletion of STL1 results in slight increase in cell size and increase in intracellular pH
      Title: The role of glycerol transporters in yeast cells in various physiological and stress conditions.
    3. Relief of glucose repression by high temperature at the level of Stl1p protein expression and activity.
      Title: Glucose repression over Saccharomyces cerevisiae glycerol/H+ symporter gene STL1 is overcome by high temperature.
    4. glycerol proton symporter in Saccharomyces cerevisiae is encoded by STL1
      Title: A member of the sugar transporter family, Stl1p is the glycerol/H+ symporter in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carbohydrate:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables solute:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables solute:proton symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerol transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organic substance transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glucose-inactivated glycerol proton symporter STL1
    NP_010825.3
    • Glycerol proton symporter of the plasma membrane; subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1508005..1509714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180844.3 → NP_010825.3  TPA: glucose-inactivated glycerol proton symporter STL1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010825.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTF6, E9P950, P39932
      UniProtKB/TrEMBL
      A0A6L0YIE2, C7GST5, G2WBR2, N1PAM1
      Conserved Domains (1) summary
      pfam00083
      Location:32 → 488
      Sugar_tr; Sugar (and other) transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39932.2

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