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    5-HT7 5-hydroxytryptamine (serotonin) receptor 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43669, updated on 10-May-2024

    Summary

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    Official Symbol
    5-HT7provided by FlyBase
    Official Full Name
    5-hydroxytryptamine (serotonin) receptor 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0004573
    Locus tag
    Dmel_CG12073
    See related
    AllianceGenome:FB:FBgn0004573
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    5-HT-7; 5-HT-dro; 5-HT-dro1; 5-HT2A; 5-HT7Dro; 5-HTdro1; 5-HT[7]Dro; 5-HT[[7Dro]]; 5-HT[[7]]; 5-HT[[7]]Dro; 5-HT[[7]]R; 5-HT[[dro1]]; 5HT-7; 5HT-dro; 5HT-dro1; 5HT-R1; 5HT7; 5htdror; 5HT[[7Dro]]; CG12073; Dm5-HT7; Dm5-HT[[7]]; Dm5HTdro1; Dmel\CG12073; DRO1; HT7
    Summary
    Enables G protein-coupled serotonin receptor activity. Involved in mating behavior and serotonin receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in adult head; central nervous system; embryonic/larval midgut interstitial cell; larval midline neurons; and ventral midline of embryo. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to several human genes including HTR7 (5-hydroxytryptamine receptor 7). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See 5-HT7 in Genome Data Viewer
    Location:
    100B1-100B1; 3-102 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30968236..31016875, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26793958..26842597, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Copper transporter 1C Neighboring gene long non-coding RNA:CR46116 Neighboring gene long non-coding RNA:CR46117 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Calcineurin A1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Serotonin receptor 5-HT7 in Drosophila mushroom body neurons mediates larval appetitive olfactory learning. Ganguly A, et al. Sci Rep, 2020 Dec 4. PMID 33277559, Free PMC Article
    2. Cloning and characterization of a Drosophila serotonin receptor that activates adenylate cyclase. Witz P, et al. Proc Natl Acad Sci U S A, 1990 Nov. PMID 2174167, Free PMC Article
    3. Expression of the Human Serotonin 5-HT(7) Receptor Rescues Phenotype Profile and Restores Dysregulated Biomarkers in a Drosophila melanogaster Glioma Model. Courant F, et al. Cells, 2022 Apr 9. PMID 35455961, Free PMC Article
    4. Serotonergic neurons respond to nutrients and regulate the timing of steroid hormone biosynthesis in Drosophila. Shimada-Niwa Y, et al. Nat Commun, 2014 Dec 15. PMID 25502946, Free PMC Article
    5. Cell-specific manipulation of second messengers; a toolbox for integrative physiology in Drosophila. Kerr M, et al. Curr Biol, 2004 Aug 24. PMID 15324663

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 5-HT(7)Dro activity is essential for normal courtship and mating behaviors in the fly
      Title: The serotonin 5-HT7Dro receptor is expressed in the brain of Drosophila, and is essential for normal courtship and mating.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled amine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled serotonin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables G protein-coupled serotonin receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating serotonin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior, orientation prior to leg tapping and wing vibration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior, proboscis-mediated licking IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior, veined wing vibration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in serotonin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in serotonin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    5-hydroxytryptamine (serotonin) receptor 7
    Names
    5-HT7-PA
    5-HT7-PB
    CG12073-PA
    CG12073-PB
    serotonin receptor
    serotonin receptor 1
    serotonin receptor 7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30968236..31016875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276202.1 → NP_001263131.1  5-hydroxytryptamine (serotonin) receptor 7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263131.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P20905, Q9VA21
      UniProtKB/TrEMBL
      A0A0B4KHG3
      Conserved Domains (2) summary
      pfam00001
      Location:179 → 507
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:173 → 342
      7tm_4; Olfactory receptor

    2. NM_079860.3 → NP_524599.1  5-hydroxytryptamine (serotonin) receptor 7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524599.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P20905, Q9VA21
      UniProtKB/TrEMBL
      A0A0B4KHG3
      Related
      FBpp0085108
      Conserved Domains (2) summary
      pfam00001
      Location:179 → 507
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:173 → 342
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHG3 A0A0B4KHG3
    P20905.1 P20905

    Gene LinkOut

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