Rasgrp1 RAS guanyl releasing protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rasgrp1provided by RGD
Official Full Name: RAS guanyl releasing protein 1provided by RGD
Primary source: RGD:3539
See related: Ensembl:ENSRNOG00000005404 AllianceGenome:RGD:3539
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rasgrp
Summary: Predicted to enable several functions, including cation binding activity; diacylglycerol binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including positive regulation of cytokine production; positive regulation of intracellular signal transduction; and positive regulation of lymphocyte differentiation. Predicted to act upstream of or within several processes, including activation of GTPase activity; mast cell degranulation; and regulation of phosphatidylinositol 3-kinase signaling. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 64. Orthologous to human RASGRP1 (RAS guanyl releasing protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 342.5), Thymus (RPKM 328.1) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (124624039..124684079, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (104168549..104230107, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (108984029..109044420, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RasGRP1 is a diacylglycerol/phorbol ester receptor in epidermal keratinocytes
Title: RasGRP1 represents a novel non-protein kinase C phorbol ester signaling pathway in mouse epidermal keratinocytes.
contribution of these two lipid pools to PLC-dependent Ras activation in response to TCR triggering
Title: Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes.

Submit: New GeneRIF Correction

General gene information

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Markers

AU048142 (e-PCR)
- UniSTS:109830

D3Wox41 (e-PCR)
- UniSTS:518963

BF412005 (e-PCR)
- UniSTS:248153

D3Got61 (e-PCR)
- UniSTS:115042

Rasgrp1 (e-PCR), detects polymorphism
- UniSTS:508519

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables diacylglycerol binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol binding	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell activation	ISO Inferred from Sequence Orthology more info
involved_in B cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in mast cell degranulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell activation	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation in thymus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in secretory granule localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within secretory granule localization	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vesicle transport along microtubule	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vesicle transport along microtubule	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RAS guanyl-releasing protein 1

Names: CalDAG-GEF1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); calDAG-GEFII; calcium and DAG-regulated guanine nucleotide exchange factor II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019211.4 → NP_062084.2 RAS guanyl-releasing protein 1

See identical proteins and their annotated locations for NP_062084.2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

O88469, Q9R1K8

UniProtKB/TrEMBL

A6HP95

Related

ENSRNOP00000007687.5, ENSRNOT00000007687.5

Conserved Domains (5) summary

smart00147
Location:201 → 437

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:54 → 176

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00051
Location:474 → 521

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00130
Location:542 → 591

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam13499
Location:478 → 526

EF-hand_7; EF-hand domain pair