ahr1a aryl hydrocarbon receptor 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ahr1aprovided by ZNC
Official Full Name: aryl hydrocarbon receptor 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020531-2
See related: Ensembl:ENSDARG00000020046 AllianceGenome:ZFIN:ZDB-GENE-020531-2
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: AHR2; ahr1; ahra; zfAHR1
Summary: Predicted to enable DNA binding activity; DNA-binding transcription factor activity; and protein dimerization activity. Acts upstream of or within cellular response to organic cyclic compound. Predicted to be located in cytoplasm. Predicted to be part of aryl hydrocarbon receptor complex and transcription regulator complex. Predicted to be active in nucleus. Is expressed in brain; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in retinitis pigmentosa 85. Orthologous to human AHR (aryl hydrocarbon receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (20009938..20038280, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (20206371..20232444, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings suggest that ahr1 genes do not have overlapping functions with ahr2 in fin and craniofacial development or TCDD-dependent toxicity, and that estrogen receptors are not constitutive partners of ahr2.
Title: ahr2, But Not ahr1a or ahr1b, Is Required for Craniofacial and Fin Development and TCDD-dependent Cardiotoxicity in Zebrafish.
Knockdown of AHR1A did not impact the mRNA expression of CYP1A, CYP1B1, and CYP1C1 in exposed embryos, but it did result in increased CYP1 activity in exposed embryos
Title: Knockdown of AHR1A but not AHR1B exacerbates PAH and PCB-126 toxicity in zebrafish (Danio rerio) embryos.
Site directed mutagenesis facilitated comparative structure-function analysis of ahr1a and ahr2 of Danio rerio, revealing the importance of specific binding site residues.
Title: Comparative analysis of homology models of the AH receptor ligand binding domain: verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor.

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General gene information

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Markers

Z10036 (e-PCR)
- UniSTS:204689

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
NOT enables ligand-activated transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to organic cyclic compound	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aryl hydrocarbon receptor 1a; aryl hydrocarbon receptor

Names: aryl hydrocarbon receptor a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

20009938..20038280 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021466612.1 → XP_021322287.1 aryl hydrocarbon receptor isoform X1

UniProtKB/TrEMBL

A0A8M9NZ29, Q8QGQ3

Conserved Domains (3) summary

smart00353
Location:33 → 74

HLH; helix loop helix domain

smart00091
Location:105 → 168

PAS; PAS domain

cl25986
Location:274 → 378

PAS_3; PAS fold
NM_131028.2 → NP_571103.2

UniProtKB/TrEMBL

A0A8N7UZF6, Q8QGQ3

Conserved Domains (5) summary

smart00353
Location:33 → 74

HLH; helix loop helix domain

smart00091
Location:105 → 167

PAS; PAS domain

cd00130
Location:285 → 373

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00989
Location:103 → 167

PAS; PAS fold

pfam14598
Location:274 → 378

PAS_11; PAS domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_131028.2: Suppressed sequence

Description

NM_131028.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.