erbb2 erb-b2 receptor tyrosine kinase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: erbb2provided by ZNC
Official Full Name: erb-b2 receptor tyrosine kinase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-031118-121
See related: Ensembl:ENSDARG00000026294 AllianceGenome:ZFIN:ZDB-GENE-031118-121
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63601; wu:fv70f10
Summary: Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within animal organ development; fin regeneration; and nervous system development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in basal plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including anterior segment eye; cranial ganglion; fin; heart; and primary neurons. Human ortholog(s) of this gene implicated in carcinoma (multiple); dilated cardiomyopathy; high grade glioma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (9360321..9438090, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (9322478..9400247, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart.
Title: Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart.
Loss of zinc finger protein multitype 1 (Zfpm1) activity resulted in over-activation of Neuregulin-ErbB signaling and abnormally elevated cardiomyocyte proliferation.
Title: The zinc finger protein Zfpm1 modulates ventricular trabeculation through Neuregulin-ErbB signalling.
Newly synthesized N-cadherin molecules move from the lateral to the basal surface of cardiomyocytes during trabeculation. This localization requires Erbb2 signaling.
Title: N-cadherin relocalization during cardiac trabeculation.
these results suggest that Nrg1 is not the primary effector of trabeculation and/or that other EGF-like ligand(s) activates the ErbB2/ErbB4 pathway, either through functioning as the primary ligand or acting in a redundant manner. Overall, our work provides an example of cross-species differences in EGF family member requirements for an evolutionary conserved process.
Title: IgG-Containing Isoforms of Neuregulin-1 Are Dispensable for Cardiac Trabeculation in Zebrafish.
Embryos homozygous for a GBT insertion within neuregulin 2a (nrg2a) revealed a novel requirement for a Neuregulin 2a (Nrg2a)-ErbB2/3-AKT signaling pathway governing the organization of a subset of epidermal cells during median fin fold morphogenesis.
Title: Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis.
A direct link was found between Erbb2 activity and remodeling of myofibrils.
Title: Actin binding GFP allows 4D in vivo imaging of myofilament dynamics in the zebrafish heart and the identification of Erbb2 signaling as a remodeling factor of myofibril architecture.
Study shows that, in addition to its role in cardiomyocyte proliferation, ErbB2 is also required for regulating cardiomyocyte migration (delamination) to initiate cardiac trabeculation.
Title: A dual role for ErbB2 signaling in cardiac trabeculation.
NRG1 and PI3K functionally interact with ErbB2 and ErbB3 during regeneration
Title: ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration.
erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish.
Title: erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish.

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General gene information

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Markers

fc05a08.y1 (e-PCR)
- UniSTS:192191

G45437 (e-PCR)
- UniSTS:106239

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERBB signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Schwann cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Schwann cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration involved in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart trabecula formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myelination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myelination of anterior lateral line nerve axons	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myelination of posterior lateral line nerve axons	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within non-myelinated axon ensheathment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within posterior lateral line neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in basal plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: receptor tyrosine-protein kinase erbB-2

Names: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

NP_956413.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200119.2 → NP_956413.2 receptor tyrosine-protein kinase erbB-2 precursor

See identical proteins and their annotated locations for NP_956413.2

Status: PROVISIONAL

Source sequence(s)

AY914799

UniProtKB/TrEMBL

Q5EBY4

Related

ENSDARP00000010252.5, ENSDART00000003932.6

Conserved Domains (7) summary

smart00261
Location:556 → 599

FU; Furin-like repeats

cd00064
Location:227 → 267

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

cd05109
Location:705 → 983

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:181 → 335

Furin-like; Furin-like cysteine rich region

pfam01030
Location:54 → 167

Recep_L_domain; Receptor L domain

pfam07714
Location:713 → 969

Pkinase_Tyr; Protein tyrosine kinase

pfam14843
Location:506 → 636

GF_recep_IV; Growth factor receptor domain IV