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    prkg3 protein kinase cGMP-dependent 3 [ Danio rerio (zebrafish) ]

    Gene ID: 326020, updated on 11-Apr-2024

    Summary

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    Official Symbol
    prkg3provided by ZNC
    Official Full Name
    protein kinase cGMP-dependent 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4745
    See related
    Ensembl:ENSDARG00000014232 AllianceGenome:ZFIN:ZDB-GENE-030131-4745
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fd58b04; wu:fd58b04; si:dkey-121j17.5
    Summary
    Predicted to enable ATP binding activity; cGMP binding activity; and cGMP-dependent protein kinase activity. Predicted to act upstream of or within protein phosphorylation. Is expressed in gall bladder; intestine; kidney; ovary; and testis. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See prkg3 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (616094..647352, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (640653..657207, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing 2b Neighboring gene potassium channel, subfamily K, member 2b Neighboring gene uncharacterized LOC110438173 Neighboring gene neural retina leucine zipper Neighboring gene SUMO specific peptidase 6a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The role of PKG in oocyte maturation of zebrafish. Li J, et al. Biochem Biophys Res Commun, 2018 Oct 28. PMID 30269816
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cGMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cGMP-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein kinase A signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cGMP-dependent protein kinase 1; cGMP-dependent protein kinase 1-like
    XP_017208033.2
    XP_021324230.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      616094..647352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017352544.2 → XP_017208033.2  cGMP-dependent protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z2R2
      Conserved Domains (2) summary
      cd00038
      Location:173 → 282
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:444 → 699
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)

    2. XM_021468555.1 → XP_021324230.1  cGMP-dependent protein kinase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PT30
      Related
      ENSDARP00000020894.5, ENSDART00000017857.7
      Conserved Domains (2) summary
      cd00038
      Location:107 → 216
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:378 → 633
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    Nucleotide Protein Strain
    Heading Accession and Version

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