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    il12bb interleukin 12B, b [ Danio rerio (zebrafish) ]

    Gene ID: 335994, updated on 27-Mar-2024

    Summary

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    Official Symbol
    il12bbprovided by ZNC
    Official Full Name
    interleukin 12B, bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7937
    See related
    Ensembl:ENSDARG00000054542 AllianceGenome:ZFIN:ZDB-GENE-030131-7937
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    il-12p40.a
    Summary
    Predicted to enable cytokine receptor activity and interleukin-12 alpha subunit binding activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to be located in extracellular space. Predicted to be part of interleukin-12 complex; interleukin-23 complex; and receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in digestive system; gill; immune system; and muscle. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Orthologous to human IL12B (interleukin 12B). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See il12bb in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (35291577..35302358)
    105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_008805539.1 (18874..22020, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene adrenoceptor beta 2, surface b Neighboring gene ubiquitin domain containing 2 Neighboring gene ubiquitin-like domain containing CTD phosphatase 1 Neighboring gene arginyl-tRNA synthetase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Discovery of zebrafish (Danio rerio) interleukin-23 alpha (IL-23α) chain, a subunit important for the formation of IL-23, a cytokine involved in the development of Th17 cells and inflammation. Holt A, et al. Mol Immunol, 2011 Apr. PMID 21324528
    2. Cloning, promoter analysis and expression in response to bacterial exposure of sea bass (Dicentrarchus labrax L.) interleukin-12 p40 and p35 subunits. Nascimento DS, et al. Mol Immunol, 2007 Mar. PMID 17196658
    3. Transcriptomic Responses of Bisphenol S Predict Involvement of Immune Function in the Cardiotoxicity of Early Life-Stage Zebrafish (Danio rerio). Qiu W, et al. Environ Sci Technol, 2020 Mar 3. PMID 31888327
    4. RNAseq Profiling of Leukocyte Populations in Zebrafish Larvae Reveals a cxcl11 Chemokine Gene as a Marker of Macrophage Polarization During Mycobacterial Infection. Rougeot J, et al. Front Immunol, 2019. PMID 31110502, Free PMC Article
    5. Evolution of Class I cytokine receptors. Liongue C, et al. BMC Evol Biol, 2007 Jul 18. PMID 17640376, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin 12B, b; interleukin-12 subunit beta
    Names
    interleukin 12 receptor p40.a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      35291577..35302358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469219.1 → XP_021324894.1  interleukin-12 subunit beta

      UniProtKB/TrEMBL
      A0A8M9PV11
      Related
      ENSDARP00000129182.2, ENSDART00000155140.3
      Conserved Domains (1) summary
      pfam10420
      Location:118 → 194
      IL12p40_C; Cytokine interleukin-12p40 C-terminus

    2. XM_021469220.1 → XP_021324895.1  interleukin-12 subunit beta

      UniProtKB/TrEMBL
      A0A8M9PV11
      Related
      ENSDARP00000071221.5, ENSDART00000076750.6
      Conserved Domains (1) summary
      pfam10420
      Location:118 → 194
      IL12p40_C; Cytokine interleukin-12p40 C-terminus

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395096.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      272105..284312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473440.1 → XP_021329115.1  interleukin-12 subunit beta

      UniProtKB/TrEMBL
      A0A8M9Q7B2
      Conserved Domains (1) summary
      pfam10420
      Location:118 → 194
      IL12p40_C; Cytokine interleukin-12p40 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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