elavl1a ELAV like RNA binding protein 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: elavl1aprovided by ZNC
Official Full Name: ELAV like RNA binding protein 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-245
See related: Ensembl:ENSDARG00000038695 AllianceGenome:ZFIN:ZDB-GENE-990415-245
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hua; elra; zHuA; elavl1; fa25f08; fb59a02; fc60g02; wu:fa25f08; wu:fb59a02; wu:fc60g02
Summary: Predicted to enable RNA binding activity. Acts upstream of or within erythrocyte differentiation and positive regulation of angiogenesis. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Is expressed in oocyte. Orthologous to human ELAVL1 (ELAV like RNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (37123338..37134217, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (37140881..37151734, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ELAVL1 promotes LPS-induced endothelial cells injury through modulation of cytokine storm.
Title: ELAVL1 promotes LPS-induced endothelial cells injury through modulation of cytokine storm.
ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection.
Title: ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection.
this study reveals a posttranscriptional regulatory mechanism by which RNA-binding protein Elavl1a regulates embryonic erythropoiesis by maintaining appropriate levels of gata1 expression.
Title: Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1.

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General gene information

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Markers

fc60g02 (e-PCR)
- UniSTS:189467

elra (e-PCR)
- UniSTS:186948

elavl1 (e-PCR), detects polymorphism
- UniSTS:205642

fc70b08.x1 (e-PCR)
- UniSTS:188235

fb59a02 (e-PCR)
- UniSTS:187255

elrA (e-PCR)
- UniSTS:204726

fa25f08.s1 (e-PCR)
- UniSTS:202482

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect RNA stabilization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ELAV-like protein 1; ELAV-like protein 1a

Names: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); ELAV like RNA binding protein 1; elav-related A; embryonic lethal, abnormal vision-related A; etID309757.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131452.1 → NP_571527.1 ELAV-like protein 1a

See identical proteins and their annotated locations for NP_571527.1

Status: PROVISIONAL

Source sequence(s)

AF184244

UniProtKB/TrEMBL

Q9PTK5

Related

ENSDARP00000040426.5, ENSDART00000040427.6

Conserved Domains (4) summary

cd12650
Location:17 → 94

RRM1_Hu; RNA recognition motif 1 in the Hu proteins family

cd12773
Location:104 → 187

RRM2_HuR; RNA recognition motif 2 in vertebrate Hu-antigen R (HuR)

TIGR01661
Location:15 → 324

ELAV_HUD_SF; ELAV/HuD family splicing factor

cl17169
Location:241 → 324

RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

37123338..37134217 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005171267.4 → XP_005171324.1 ELAV-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_005171324.1

UniProtKB/TrEMBL

A0A8M2BIL8, F1QM02

Related

ENSDARP00000120506.1, ENSDART00000146123.3

Conserved Domains (4) summary

cd12650
Location:33 → 110

RRM1_Hu; RNA recognition motif 1 in the Hu proteins family

cd12653
Location:257 → 340

RRM3_HuR; RNA recognition motif 3 in vertebrate Hu-antigen R (HuR)

cd12773
Location:120 → 203

RRM2_HuR; RNA recognition motif 2 in vertebrate Hu-antigen R (HuR)

TIGR01661
Location:31 → 340

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_005171268.4 → XP_005171325.1 ELAV-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_005171325.1

UniProtKB/TrEMBL

A0A8M2BIL8, F1QM02

Conserved Domains (4) summary

cd12650
Location:33 → 110

RRM1_Hu; RNA recognition motif 1 in the Hu proteins family

cd12653
Location:257 → 340

RRM3_HuR; RNA recognition motif 3 in vertebrate Hu-antigen R (HuR)

cd12773
Location:120 → 203

RRM2_HuR; RNA recognition motif 2 in vertebrate Hu-antigen R (HuR)

TIGR01661
Location:31 → 340

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_009298634.2 → XP_009296909.1 ELAV-like protein 1 isoform X2

UniProtKB/TrEMBL

A0A8M3AQB0

Conserved Domains (1) summary

cl17169
Location:127 → 210

RRM_SF; RNA recognition motif (RRM) superfamily
XM_017357655.1 → XP_017213144.1 ELAV-like protein 1 isoform X1

UniProtKB/TrEMBL

A0A8M2BIL8, F1QM02

Conserved Domains (4) summary

cd12650
Location:33 → 110

RRM1_Hu; RNA recognition motif 1 in the Hu proteins family

cd12653
Location:257 → 340

RRM3_HuR; RNA recognition motif 3 in vertebrate Hu-antigen R (HuR)

cd12773
Location:120 → 203

RRM2_HuR; RNA recognition motif 2 in vertebrate Hu-antigen R (HuR)

TIGR01661
Location:31 → 340

ELAV_HUD_SF; ELAV/HuD family splicing factor