slc25a4 solute carrier family 25 member 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc25a4provided by ZNC
Official Full Name: solute carrier family 25 member 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5275
See related: Ensembl:ENSDARG00000027355 AllianceGenome:ZFIN:ZDB-GENE-030131-5275
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa22e07; zgc:77591; wu:fa22e07
Summary: Predicted to enable ATP:ADP antiporter activity. Predicted to act upstream of or within mitochondrial ADP transmembrane transport and mitochondrial ATP transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be integral component of membrane. Is expressed in cephalic musculature; hypaxial myotome region; musculature system; myotome; and somite. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to human SLC25A4 (solute carrier family 25 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (17676762..17679087)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (16982102..16986155)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

aa605664 (e-PCR)
- UniSTS:186889

fa22e07.s1 (e-PCR)
- UniSTS:202477

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP:ADP antiporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mitochondrial ADP transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial ATP transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ADP/ATP translocase 1

Names: solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214702.1 → NP_999867.1 ADP/ATP translocase 1

See identical proteins and their annotated locations for NP_999867.1

Status: PROVISIONAL

Source sequence(s)

BC067329

UniProtKB/TrEMBL

A0A8M1PQQ4, Q6NX10

Related

ENSDARP00000030881.6, ENSDART00000030665.7

Conserved Domains (2) summary

PTZ00169
Location:7 → 296

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:6 → 101

Mito_carr; Mitochondrial carrier protein