meis2b Meis homeobox 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: meis2bprovided by ZNC
Official Full Name: Meis homeobox 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000210-23
See related: Ensembl:ENSDARG00000077840 AllianceGenome:ZFIN:ZDB-GENE-000210-23
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: meis2; meis2.1
Summary: Predicted to enable DNA binding activity. Acts upstream of or within cardiac atrium morphogenesis and heart looping. Predicted to be located in nucleus. Is expressed in several structures, including anterior neural keel; heart rudiment; nervous system; neural plate; and pericardial region. Human ortholog(s) of this gene implicated in cleft palate, cardiac defects, and intellectual disabillity. Orthologous to human MEIS2 (Meis homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (10099109..10120437, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (10111869..10133202, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac atrium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein Meis2b; meis homeobox 2b

Names: myeloid ecotropic viral integration site 2.1; myeloid ecotropic viral integration site 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130910.1 → NP_570985.1 homeobox protein Meis2b

See identical proteins and their annotated locations for NP_570985.1

Status: PROVISIONAL

Source sequence(s)

AF170065

UniProtKB/TrEMBL

Q9PTM7

Related

ENSDARP00000034815.5, ENSDART00000033976.7

Conserved Domains (2) summary

pfam05920
Location:293 → 332

Homeobox_KN; Homeobox KN domain

pfam16493
Location:112 → 195

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1