SLC39A10 solute carrier family 39 member 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC39A10provided by HGNC
Official Full Name: solute carrier family 39 member 10provided by HGNC
Primary source: HGNC:HGNC:20861
See related: Ensembl:ENSG00000196950 MIM:608733; AllianceGenome:HGNC:20861
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZIP10; LZT-Hs2
Summary: Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
Expression: Broad expression in thyroid (RPKM 12.9), brain (RPKM 12.5) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q32.3

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (195613029..195737700)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (196097362..196222040)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (196521682..196602424)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways.
Title: SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways.
The bZIP transcription factor BATF3/ZIP-10 suppresses innate immunity by attenuating PMK-1/p38 signaling.
Title: The bZIP transcription factor BATF3/ZIP-10 suppresses innate immunity by attenuating PMK-1/p38 signaling.
Functional characterization of SLC39 family members ZIP5 and ZIP10 in overexpressing HEK293 cells reveals selective copper transport activity.
Title: Functional characterization of SLC39 family members ZIP5 and ZIP10 in overexpressing HEK293 cells reveals selective copper transport activity.
ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway.
Title: ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway.
The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis.
Title: The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis.
Possible involvement of zinc transporter ZIP10 in atopic dermatitis.
Title: Possible involvement of zinc transporter ZIP10 in atopic dermatitis.
ZIP10 is found in the proximal tubules collecting duct system and has a role in renal zinc transport.
Title: Cloning, function, and localization of human, canine, and Drosophila ZIP10 (SLC39A10), a Zn(2+) transporter.
Slc39a10 plays a role in promoting the survival of macrophages through a Zn/p53-dependent axis in response to inflammatory stimuli.
Title: Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival.
A significant correlation between ZIP10 mRNA expressions with aggressiveness of RCC.
Title: Association between ZIP10 gene expression and tumor aggressiveness in renal cell carcinoma.
Zinc and its transporters, ZIP6 and ZIP10, are required for the breast cancer cells motility stimulated with high glucose level, such as in diabetes.
Title: High glucose level promotes migration behavior of breast cancer cells through zinc and its transporters.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLC39A10	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates the expression of solute carrier family 39 (zinc transporter), member 10 (SLC39A10) in human primary T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH92946 (e-PCR)
- UniSTS:92929

AB060898 (e-PCR)
- UniSTS:480021

RH69214 (e-PCR)
- UniSTS:54854

SHGC-36936 (e-PCR)
- UniSTS:65175

WI-21799 (e-PCR)
- UniSTS:82418

Clone Names

FLJ31108, MGC126565, MGC138428, DKFZp781L10106

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables monoatomic cation:bicarbonate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in bicarbonate transport	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular monoatomic cation homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of B cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in zinc ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc transporter ZIP10

Names: ZIP-10; ZRT/IRT-like protein 10; solute carrier family 39 (metal ion transporter), member 10; solute carrier family 39 (zinc transporter), member 10; zinc transporter 10; zrt- and Irt-like protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127257.2 → NP_001120729.1 zinc transporter ZIP10 precursor

See identical proteins and their annotated locations for NP_001120729.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC013274, AI693720, CR749813

Consensus CDS

CCDS33353.1

UniProtKB/Swiss-Prot

A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1

Related

ENSP00000386766.3, ENST00000409086.7

Conserved Domains (1) summary

pfam02535
Location:404 → 819

Zip; ZIP Zinc transporter
NM_020342.3 → NP_065075.1 zinc transporter ZIP10 precursor

See identical proteins and their annotated locations for NP_065075.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC013274, AI693720, AK291241

Consensus CDS

CCDS33353.1

UniProtKB/Swiss-Prot

A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1

Related

ENSP00000352655.5, ENST00000359634.10

Conserved Domains (1) summary

pfam02535
Location:404 → 819

Zip; ZIP Zinc transporter