Hal histidine ammonia lyase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Halprovided by RGD
Official Full Name: histidine ammonia lyaseprovided by RGD
Primary source: RGD:68363
See related: Ensembl:ENSRNOG00000004502 AllianceGenome:RGD:68363
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: histidase
Summary: Enables histidine ammonia-lyase activity. Predicted to be involved in histidine catabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in histidinemia. Orthologous to human HAL (histidine ammonia-lyase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 507.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q13

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (29894495..29924744)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (28007449..28037701)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (34326087..34356413)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This evidence supports that the Hal gene is turned on by glucocorticoids and by glucagon either via PKC or PKA, but prefers the PKA pathway.
Title: Regulation by glucagon of the rat histidase gene promoter in cultured rat hepatocytes and human hepatoblastoma cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histidine ammonia-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histidine ammonia-lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables histidine ammonia-lyase activity	ISO Inferred from Sequence Orthology more info
enables histidine ammonia-lyase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in histidine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within histidine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in histidine catabolic process to glutamate and formamide	IEA Inferred from Electronic Annotation more info
involved_in histidine catabolic process to glutamate and formate	IEA Inferred from Electronic Annotation more info
involved_in histidine metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histidine ammonia-lyase

NP_058855.1

EC 4.3.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017159.1 → NP_058855.1 histidine ammonia-lyase

See identical proteins and their annotated locations for NP_058855.1

Status: PROVISIONAL

Source sequence(s)

M58308

UniProtKB/Swiss-Prot

P21213, Q5EBB8

UniProtKB/TrEMBL

A6IFY6

Related

ENSRNOP00000006971.4, ENSRNOT00000006971.7

Conserved Domains (2) summary

TIGR01225
Location:114 → 625

hutH; histidine ammonia-lyase

pfam12053
Location:15 → 78

DUF3534; N-terminal of Par3 and HAL proteins