Dcn decorin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dcnprovided by RGD
Official Full Name: decorinprovided by RGD
Primary source: RGD:61895
See related: Ensembl:ENSRNOG00000004554 AllianceGenome:RGD:61895
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables collagen binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; response to lipopolysaccharide; and wound healing. Located in extracellular matrix. Part of collagen type VI trimer. Biomarker of asthma; myocardial infarction; and obesity. Human ortholog(s) of this gene implicated in breast carcinoma; congenital stromal corneal dystrophy; and high grade glioma. Orthologous to human DCN (decorin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 4148.5), Uterus (RPKM 3348.4) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (34167973..34208004)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (32281252..32321291)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (38742250..38782282)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction.
Title: The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction.
Decorin Protects Cardiac Myocytes against Simulated Ischemia/Reperfusion Injury.
Title: Decorin Protects Cardiac Myocytes against Simulated Ischemia/Reperfusion Injury.
overexpression of decorin ameliorated diabetic cardiomyopathy and promoted angiogenesis through the IGF1R-AKT-VEGF signaling pathway in vivo and in vitro.
Title: Overexpression of decorin promoted angiogenesis in diabetic cardiomyopathy via IGF1R-AKT-VEGF signaling.
The spatio-temporal expression of Decorin, Semaphorin6D, SPARC, Spry-1 and Tsukushi in developing prostate is described and observed similar mesenchymal expression patterns in rat and human.
Title: Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer.
Data show that the overexpression of OTUB1 enhanced the ubiquitination and degradation of Decorin (DCN)in mesangial cells (MC).
Title: OTUB1 overexpression in mesangial cells is a novel regulator in the pathogenesis of glomerulonephritis through the decrease of DCN level.
Regulating the ubiquitination and degradation of DCN might be a novel approach for modulating mesangial cell bioactivity.
Title: Regulation of intracellular decorin via proteasome degradation in rat mesangial cells.
analysis of the high-resolution model of the decoron-fibril collagen complex
Title: Decorin core protein (decoron) shape complements collagen fibril surface structure and mediates its binding.
Decorin expression was significantly decreased on rat vocal fold postinjury days 1, 3, 7, and 56.
Title: Extracellular matrix gene expression during wound healing of the injured rat vocal fold.
Overexpression of decorin could inhibit mesangial cell proliferation by inducing apoptosis and cell growth arrest in vitro and it also downregulates expression of TGF-beta1.
Title: Overexpression of decorin induces apoptosis and cell growth arrest in cultured rat mesangial cells in vitro.
These results suggest that decorin participates in the quiescence of myogenic cells.
Title: Decorin expression in quiescent myogenic cells.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU047216 (e-PCR)
- UniSTS:110726

AA799757 (e-PCR)
- UniSTS:250290

RH128134 (e-PCR)
- UniSTS:211442

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables extracellular matrix binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix binding	ISO Inferred from Sequence Orthology more info
enables glycosaminoglycan binding	IEA Inferred from Electronic Annotation more info
enables glycosaminoglycan binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in placenta development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macroautophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial depolarization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of collagen type VI trimer	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: decorin

Names: DSPG; PG-S2; PG40; bone proteoglycan II; dermatan sulfate proteoglycan-II (decorin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024129.1 → NP_077043.1 decorin precursor

See identical proteins and their annotated locations for NP_077043.1

Status: PROVISIONAL

Source sequence(s)

BC083750

UniProtKB/Swiss-Prot

Q01129

UniProtKB/TrEMBL

A6IG64

Related

ENSRNOP00000006070.4, ENSRNOT00000006070.7

Conserved Domains (3) summary

PRK15370
Location:65 → 329

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00013
Location:48 → 80

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:57 → 77

LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

34167973..34208004

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241285.2 → XP_006241347.1 decorin isoform X3

See identical proteins and their annotated locations for XP_006241347.1

UniProtKB/Swiss-Prot

Q01129

UniProtKB/TrEMBL

A6IG64

Conserved Domains (3) summary

PRK15370
Location:65 → 329

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00013
Location:48 → 80

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:57 → 77

LRR_RI; leucine-rich repeat [structural motif]
XM_063263107.1 → XP_063119177.1 decorin isoform X2

UniProtKB/TrEMBL

A0A8I6AAW0
XM_063263106.1 → XP_063119176.1 decorin isoform X1

UniProtKB/TrEMBL

A0A8I6GFI0