U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    fum-1 putative fumarate hydratase, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 176059, updated on 12-Jun-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    fum-1
    Gene description
    putative fumarate hydratase, mitochondrial
    Locus tag
    CELE_H14A12.2
    See related
    AllianceGenome:WB:WBGene00001503
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fumarate hydratase activity. Predicted to be involved in fumarate metabolic process; malate metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Orthologous to human FH (fumarate hydratase). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See fum-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (7465605..7467640)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene Protein rogdi homolog Neighboring gene ncRNA Neighboring gene tRNA-synt_2 domain-containing protein Neighboring gene Transmembrane matrix receptor MUP-4 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Joint mouse-human phenome-wide association to test gene function and disease risk. Wang X, et al. Nat Commun, 2016 Feb 2. PMID 26833085, Free PMC Article
    2. Oligonucleotide Array Comparative Genomic Hybridization (oaCGH) based characterization of genetic deficiencies as an aid to gene mapping in Caenorhabditis elegans. Jones MR, et al. BMC Genomics, 2007 Nov 7. PMID 17986355, Free PMC Article
    3. Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. Yoneda T, et al. J Cell Sci, 2004 Aug 15. PMID 15280428
    4. Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism in Caenorhabditis elegans. Castelein N, et al. Biotechnol J, 2008 Jun. PMID 18383023
    5. Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans. McElwee JJ, et al. Mech Ageing Dev, 2006 May. PMID 16522328

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fumarate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fumarate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fumarate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fumarate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of tricarboxylic acid cycle heteromeric enzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    putative fumarate hydratase, mitochondrial
    NP_498642.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7465605..7467640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066241.8 → NP_498642.1  putative fumarate hydratase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498642.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17214
      Conserved Domains (2) summary
      cd01362
      Location:42 → 497
      Fumarase_classII; Class II fumarases
      PRK00485
      Location:38 → 501
      fumC; fumarate hydratase; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17214.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous