CDK17 cyclin dependent kinase 17 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CDK17provided by HGNC
Official Full Name: cyclin dependent kinase 17provided by HGNC
Primary source: HGNC:HGNC:8750
See related: Ensembl:ENSG00000059758 MIM:603440; AllianceGenome:HGNC:8750
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PCTK2; PCTAIRE2
Summary: The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]
Expression: Ubiquitous expression in brain (RPKM 21.3), testis (RPKM 15.1) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q23.1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (96278225..96400439, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (96252431..96374639, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (96672003..96794217, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircCDK17 promotes the proliferation and metastasis of ovarian cancer cells by sponging miR-22-3p to regulate CD147 expression.
Title: CircCDK17 promotes the proliferation and metastasis of ovarian cancer cells by sponging miR-22-3p to regulate CD147 expression.
CircCDK17 knockdown inhibits tumor progression and cell glycolysis by downregulaing YWHAZ expression through sponging miR-1294 in cervical cancer.
Title: CircCDK17 knockdown inhibits tumor progression and cell glycolysis by downregulaing YWHAZ expression through sponging miR-1294 in cervical cancer.
Increased levels of PCTAIRE2 is associated with Alzheimer's disease.
Title: Potential role of PCTAIRE-2, PCTAIRE-3 and P-Histone H4 in amyloid precursor protein-dependent Alzheimer pathology.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH68952 (e-PCR)
- UniSTS:55614

PMC310794P3 (e-PCR)
- UniSTS:272719

SHGC-84689 (e-PCR)
- UniSTS:104090

STS-H95680 (e-PCR)
- UniSTS:73419

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cyclin-dependent kinase 17

Names: PCTAIRE-motif protein kinase 2; cell division protein kinase 17; protein kinase cdc2-related PCTAIRE-2; serine/threonine-protein kinase PCTAIRE-2

NP_001163935.1

EC 2.7.11.22

NP_002586.2

EC 2.7.11.22

XP_016874894.1

EC 2.7.11.22

XP_016874895.1

EC 2.7.11.22

XP_016874896.1

EC 2.7.11.22

XP_054228168.1

EC 2.7.11.22

XP_054228169.1

EC 2.7.11.22

XP_054228170.1

EC 2.7.11.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170464.4 → NP_001163935.1 cyclin-dependent kinase 17 isoform 2

See identical proteins and their annotated locations for NP_001163935.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus but is the same length as isoform 1.

Source sequence(s)

AC008149, AC125612, AF086067, AK290011, BC033005, DA530711

Consensus CDS

CCDS53819.1

UniProtKB/TrEMBL

B4DGP5

Related

ENSP00000444459.2, ENST00000543119.6

Conserved Domains (1) summary

cd07872
Location:185 → 493

STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase
NM_002595.5 → NP_002586.2 cyclin-dependent kinase 17 isoform 1

See identical proteins and their annotated locations for NP_002586.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.

Source sequence(s)

AF086067, BC033005, DC307775

Consensus CDS

CCDS9061.1

UniProtKB/Swiss-Prot

A8K1U6, B2RCQ2, Q00537, Q8NEB8

UniProtKB/TrEMBL

B4DGP5

Related

ENSP00000261211.3, ENST00000261211.8

Conserved Domains (1) summary

cd07872
Location:185 → 493

STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

96278225..96400439 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017019407.3 → XP_016874896.1 cyclin-dependent kinase 17 isoform X2

UniProtKB/TrEMBL

B4DGP5
XM_017019406.2 → XP_016874895.1 cyclin-dependent kinase 17 isoform X1

UniProtKB/Swiss-Prot

A8K1U6, B2RCQ2, Q00537, Q8NEB8

UniProtKB/TrEMBL

B4DGP5

Conserved Domains (1) summary

cd07872
Location:185 → 493

STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase
XM_017019405.2 → XP_016874894.1 cyclin-dependent kinase 17 isoform X1

UniProtKB/Swiss-Prot

A8K1U6, B2RCQ2, Q00537, Q8NEB8

UniProtKB/TrEMBL

B4DGP5

Conserved Domains (1) summary

cd07872
Location:185 → 493

STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase