atp2b1a ATPase plasma membrane Ca2+ transporting 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: atp2b1aprovided by ZNC
Official Full Name: ATPase plasma membrane Ca2+ transporting 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030925-29
See related: Ensembl:ENSDARG00000012684 AllianceGenome:ZFIN:ZDB-GENE-030925-29
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pmca1; pmca1a; sb:cb801; wu:fe47b06; wu:fi41d01; si:dkey-18o7.1
Summary: Predicted to enable P-type calcium transporter activity and PDZ domain binding activity. Acts upstream of or within animal organ development and sensory perception of sound. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. Predicted to be integral component of plasma membrane. Is expressed in several structures, including digestive system; hematopoietic system; midbrain neural tube; nervous system; and pleuroperitoneal region. Orthologous to human ATP2B1 (ATPase plasma membrane Ca2+ transporting 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (16076704..16124500, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (16077964..16125664, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activity of Atp2b1a is required to facilitate calcification of the developing pharyngeal teeth by the dental epithelium.
Title: Plasma membrane Ca(2+) ATPase Atp2b1a regulates bone mineralization in zebrafish.
Atp2b1a functions during progenitor cell proliferation and hair cell differentiation
Title: atp2b1a regulates Ca(2+) export during differentiation and regeneration of mechanosensory hair cells in zebrafish.
Atp2b1a plays an important role for normal development of the auditory and vestibular system as well as calcium transport in the inner ear of zebrafish.
Title: Plasma membrane calcium ATPase required for semicircular canal formation and otolith growth in the zebrafish inner ear.

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General gene information

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Markers

fi41d01.x1 (e-PCR)
- UniSTS:197485

fe47b06.x1 (e-PCR)
- UniSTS:196475

fj59b06.x1 (e-PCR)
- UniSTS:199629

fd49h07.y1 (e-PCR)
- UniSTS:195576

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type calcium transporter activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear receptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within otolith development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within posterior lateral line neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tooth mineralization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: plasma membrane calcium-transporting ATPase 1

Names: ATPase, Ca++ transporting, plasma membrane 1a; plasma membrane calcium ATPase 1

NP_001038222.1

EC 7.2.2.10

XP_009298531.1

EC 7.2.2.10

XP_021330639.1

EC 7.2.2.10

XP_021330640.1

EC 7.2.2.10

XP_021330641.1

EC 7.2.2.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044757.1 → NP_001038222.1 plasma membrane calcium-transporting ATPase 1

See identical proteins and their annotated locations for NP_001038222.1

Status: PROVISIONAL

Source sequence(s)

BX649423

UniProtKB/TrEMBL

B7ZVL0, F6PDY7

Related

ENSDARP00000072130.5, ENSDART00000077664.7

Conserved Domains (7) summary

TIGR01517
Location:10 → 1064

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam00122
Location:191 → 464

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:880 → 1058

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:49 → 116

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12424
Location:1105 → 1154

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

pfam12710
Location:687 → 806

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:525 → 611

Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007115.7 Reference GRCz11 Primary Assembly

Range

16076704..16124500 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021474964.1 → XP_021330639.1 plasma membrane calcium-transporting ATPase 1 isoform X1

UniProtKB/TrEMBL

A0A8M9Q0B2

Conserved Domains (2) summary

pfam12424
Location:1105 → 1182

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

cl27747
Location:10 → 1064

E1-E2_ATPase; E1-E2 ATPase
XM_021474965.1 → XP_021330640.1 plasma membrane calcium-transporting ATPase 1 isoform X2

UniProtKB/TrEMBL

A0A8M9QB28

Conserved Domains (2) summary

pfam12424
Location:1105 → 1156

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

cl27747
Location:10 → 1064

E1-E2_ATPase; E1-E2 ATPase
XM_009300256.3 → XP_009298531.1 plasma membrane calcium-transporting ATPase 1 isoform X1

See identical proteins and their annotated locations for XP_009298531.1

UniProtKB/TrEMBL

A0A8M9Q0B2

Conserved Domains (2) summary

pfam12424
Location:1105 → 1182

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

cl27747
Location:10 → 1064

E1-E2_ATPase; E1-E2 ATPase
XM_021474966.1 → XP_021330641.1 plasma membrane calcium-transporting ATPase 1 isoform X3

UniProtKB/TrEMBL

A0A8M9Q5T9

Conserved Domains (2) summary

pfam12424
Location:1105 → 1191

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

cl27747
Location:10 → 1064

E1-E2_ATPase; E1-E2 ATPase