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    kntc1 kinetochore associated 1 [ Danio rerio (zebrafish) ]

    Gene ID: 497376, updated on 27-Mar-2024

    Summary

    Official Symbol
    kntc1provided by ZNC
    Official Full Name
    kinetochore associated 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050208-92
    See related
    Ensembl:ENSDARG00000101670 AllianceGenome:ZFIN:ZDB-GENE-050208-92
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:6912223; im:7138629
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in mitotic sister chromatid segregation; mitotic spindle assembly checkpoint signaling; and protein localization to kinetochore involved in kinetochore assembly. Predicted to be part of RZZ complex. Predicted to be active in cytoplasm and kinetochore microtubule. Orthologous to human KNTC1 (kinetochore associated 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See kntc1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    61
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (66433306..66512522)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (65754179..65833414)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene huntingtin interacting protein 1 related b Neighboring gene embigin Neighboring gene uncharacterized LOC110439837 Neighboring gene meningioma 1b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to kinetochore involved in kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of RZZ complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in kinetochore microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    kinetochore-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      66433306..66512522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301982.3XP_009300257.2  kinetochore-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IHW6, A0A8M3B017
      Related
      ENSDARP00000133225.1, ENSDART00000170757.2
      Conserved Domains (1) summary
      pfam10493
      Location:15972144
      Rod_C; Rough deal protein C-terminal region
    2. XM_009301984.3XP_009300259.2  kinetochore-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0R4IHW6, A0A8M3ASW0
      Conserved Domains (1) summary
      pfam10493
      Location:15962143
      Rod_C; Rough deal protein C-terminal region
    3. XM_021476680.1XP_021332355.1  kinetochore-associated protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0R4IHW6, A0A8M9QEY6
      Conserved Domains (1) summary
      pfam10493
      Location:15882135
      Rod_C; Rough deal protein C-terminal region