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    Kcnt2 potassium sodium-activated channel subfamily T member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304827, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Kcnt2provided by RGD
    Official Full Name
    potassium sodium-activated channel subfamily T member 2provided by RGD
    Primary source
    RGD:735074
    See related
    Ensembl:ENSRNOG00000013312 AllianceGenome:RGD:735074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Slick
    Summary
    Enables chloride-activated potassium channel activity. Involved in potassium ion export across plasma membrane. Acts upstream of or within potassium ion transport. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 57. Orthologous to human KCNT2 (potassium sodium-activated channel subfamily T member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 61.0), Muscle (RPKM 12.5) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcnt2 in Genome Data Viewer
    Location:
    13q21
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (54214831..54609889)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (51664129..52059209)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (57130855..57520263)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene complement factor H Neighboring gene heterogeneous nuclear ribonucleoprotein C, pseudogene 4 Neighboring gene macrophage migration inhibitory factor, pseudogene 6 Neighboring gene U1 spliceosomal RNA Neighboring gene ribosomal protein S2, pseudogene 31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcriptional Regulation of the Sodium-activated Potassium Channel SLICK (KCNT2) Promoter by Nuclear Factor-κB. Tomasello DL, et al. J Biol Chem, 2015 Jul 24. PMID 26100633, Free PMC Article
    2. Localization of the Na+-activated K+ channel Slick in the rat central nervous system. Bhattacharjee A, et al. J Comp Neurol, 2005 Mar 28. PMID 15717307
    3. The appearance of a protein kinase A-regulated splice isoform of slo is associated with the maturation of neurons that control reproductive behavior. Zhang Y, et al. J Biol Chem, 2004 Dec 10. PMID 15375169
    4. A De Novo Mutation in the Sodium-Activated Potassium Channel KCNT2 Alters Ion Selectivity and Causes Epileptic Encephalopathy. Gururaj S, et al. Cell Rep, 2017 Oct 24. PMID 29069600, Free PMC Article
    5. The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels. Chen H, et al. J Neurosci, 2009 Apr 29. PMID 19403831, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLO2 Channels Are Inhibited by All Divalent Cations That Activate SLO1 K+ Channels
      Title: SLO2 Channels Are Inhibited by All Divalent Cations That Activate SLO1 K+ Channels.
    2. Our data show SLICK expression is predominantly under the control of NFkappaB. Because neuronal NFkappaB activation occurs during stressful stimuli such as hypoxia and injury, our findings suggest that SLICK is a neuroprotective gene.
      Title: Transcriptional Regulation of the Sodium-activated Potassium Channel SLICK (KCNT2) Promoter by Nuclear Factor-κB.
    3. Slick channels, in contrast to the similar Slack channels, are the only high-conductance K+ channels strongly sensitive to small changes in cell volume.
      Title: Cell volume changes regulate slick (Slo2.1), but not slack (Slo2.2) K+ channels.
    4. Heteromer formation between Slick and Slack-B requires a specific epitope that is found in the N-terminal domain of Slack-B and that is absent in the Slack-A isoform.
      Title: The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels.
    5. We conclude that Slack and Slick K(Na) channels are required for depolarizing afterpotential of medium diameter rat dorsal root ganglion neurons
      Title: Slack and Slick KNa channels are required for the depolarizing afterpotential of acutely isolated, medium diameter rat dorsal root ganglion neurons.
    6. Cloning and regulation of slick channel activity.
      Title: Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP.
    7. we report the localization of Slick in the rat central nervous system using in situ and immunohistochemical techniques
      Title: Localization of the Na+-activated K+ channel Slick in the rat central nervous system.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables chloride-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chloride-activated potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables chloride-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables intracellular sodium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellular sodium-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables intracellular sodium-activated potassium channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables ligand-gated monoatomic cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion-gated channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion export across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    potassium channel subfamily T member 2
    Names
    potassium channel, sodium-activated subfamily T, member 2
    potassium channel, subfamily T, member 2
    sequence like an intermediate conductance potassium channel subunit
    sodium and chloride-activated ATP-sensitive potassium channel Slo2.1
    sodium- and chloride-activated ATP-sensitive potassium channel

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198762.2 → NP_942057.2  potassium channel subfamily T member 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q6UVM4
      Related
      ENSRNOP00000071443.2, ENSRNOT00000083693.2
      Conserved Domains (3) summary
      pfam00520
      Location:63 → 270
      Ion_trans; Ion transport protein
      pfam03493
      Location:424 → 526
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:228 → 272
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      54214831..54609889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090726.2 → XP_038946654.1  potassium channel subfamily T member 2 isoform X6

      Conserved Domains (2) summary
      pfam03493
      Location:449 → 551
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:253 → 297
      Ion_trans_2; Ion channel

    2. XM_017598802.3 → XP_017454291.1  potassium channel subfamily T member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6UVM4

    3. XM_017598803.3 → XP_017454292.1  potassium channel subfamily T member 2 isoform X3

      UniProtKB/Swiss-Prot
      Q6UVM4

    4. XM_039090728.2 → XP_038946656.1  potassium channel subfamily T member 2 isoform X8

      Conserved Domains (2) summary
      pfam03493
      Location:449 → 551
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:253 → 297
      Ion_trans_2; Ion channel

    5. XM_063272313.1 → XP_063128383.1  potassium channel subfamily T member 2 isoform X9

      UniProtKB/Swiss-Prot
      Q6UVM4
      UniProtKB/TrEMBL
      A0A8I6AJ80

    6. XM_017598804.3 → XP_017454293.1  potassium channel subfamily T member 2 isoform X4

      UniProtKB/Swiss-Prot
      Q6UVM4

    7. XM_039090723.2 → XP_038946651.1  potassium channel subfamily T member 2 isoform X2

      UniProtKB/Swiss-Prot
      Q6UVM4
      Conserved Domains (3) summary
      pfam00520
      Location:63 → 295
      Ion_trans; Ion transport protein
      pfam03493
      Location:449 → 551
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:253 → 297
      Ion_trans_2; Ion channel

    8. XM_006249943.5 → XP_006250005.1  potassium channel subfamily T member 2 isoform X5

      UniProtKB/Swiss-Prot
      Q6UVM4
      UniProtKB/TrEMBL
      A0A8L2UJ52
      Related
      ENSRNOP00000017884.6
      Conserved Domains (2) summary
      pfam03493
      Location:431 → 526
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:226 → 272
      Ion_trans_2; Ion channel

    9. XM_039090727.2 → XP_038946655.1  potassium channel subfamily T member 2 isoform X7

      Conserved Domains (1) summary
      pfam03493
      Location:50 → 152
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    RNA

    1. XR_005492244.2 RNA Sequence

    2. XR_010056918.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UVM4.1 GenPept UniProtKB/Swiss-Prot:Q6UVM4

    Gene LinkOut

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