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    Eato Engulfment ABC Transporter in the ovary [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34783, updated on 10-May-2024

    Summary

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    Official Symbol
    Eatoprovided by FlyBase
    Official Full Name
    Engulfment ABC Transporter in the ovaryprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028539
    Locus tag
    Dmel_CG31731
    See related
    AllianceGenome:FB:FBgn0028539
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS00797.5; CG31731; CG7491; CG7559; D00797.5; DmCG31731; Dmel\CG31731; DS00797.5
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Located in plasma membrane. Is expressed in adult head; organism; and spermatozoon. Human ortholog(s) of this gene implicated in Alzheimer's disease 9; fundus dystrophy; and retinal degeneration (multiple). Orthologous to several human genes including ABCA10 (ATP binding cassette subfamily A member 10); ABCA4 (ATP binding cassette subfamily A member 4); and ABCA5 (ATP binding cassette subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Eato in Genome Data Viewer
    Location:
    34D1-34D1; 2-49 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13784084..13790562)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13784084..13790562)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR31845 Neighboring gene p38b MAP kinase Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44847 Neighboring gene uncharacterized protein Neighboring gene Secretory 71

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ABC Transporter Eato Promotes Cell Clearance in the Drosophila melanogaster Ovary. Santoso CS, et al. G3 (Bethesda), 2018 Mar 2. PMID 29295819, Free PMC Article
    2. Murder on the Ovarian Express: A Tale of Non-Autonomous Cell Death in the Drosophila Ovary. Lebo DPV, et al. Cells, 2021 Jun 10. PMID 34200604, Free PMC Article
    3. Drosophila TAP/p32 is a core histone chaperone that cooperates with NAP-1, NLP, and nucleophosmin in sperm chromatin remodeling during fertilization. Emelyanov AV, et al. Genes Dev, 2014 Sep 15. PMID 25228646, Free PMC Article
    4. Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes. Moulton MJ, et al. Proc Natl Acad Sci U S A, 2021 Dec 28. PMID 34949639, Free PMC Article
    5. Genome annotation assessment in Drosophila melanogaster. Reese MG, et al. Genome Res, 2000 Apr. PMID 10779488, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    engulfment ABC transporter in the ovary
    Names
    CG31731-PB
    CG31731-PC
    Eato-PB
    Eato-PC
    NP_001036360.1
    NP_001162974.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13784084..13790562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042895.3 → NP_001036360.1  engulfment ABC transporter in the ovary, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036360.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8Q7
      Conserved Domains (4) summary
      TIGR01188
      Location:1262 → 1573
      drrA; daunorubicin resistance ABC transporter ATP-binding subunit
      cd03263
      Location:1255 → 1479
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      COG1131
      Location:460 → 767
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam12698
      Location:937 → 1117
      ABC2_membrane_3; ABC-2 family transporter protein

    2. NM_001169503.2 → NP_001162974.1  engulfment ABC transporter in the ovary, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162974.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHH7
      Conserved Domains (1) summary
      pfam12698
      Location:209 → 347
      ABC2_membrane_3; ABC-2 family transporter protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHH7 E1JHH7
    Q0E8Q7 Q0E8Q7
    Q960V4 Q960V4

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