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    Asb2 ankyrin repeat and SOCS box-containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299266, updated on 25-Apr-2024

    Summary

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    Symbol
    Asb2provided by RGD
    Full Name
    ankyrin repeat and SOCS box-containing 2provided by RGD
    Primary source
    RGD:1306414
    See related
    Ensembl:ENSRNOG00000051619 AllianceGenome:RGD:1306414
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cullin family protein binding activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; heart development; and podosome assembly. Predicted to act upstream of or within myoblast differentiation; protein polyubiquitination; and skeletal muscle cell differentiation. Predicted to be located in Z disc. Predicted to be part of Cul5-RING ubiquitin ligase complex. Orthologous to human ASB2 (ankyrin repeat and SOCS box containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 766.4), Heart (RPKM 560.6) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Asb2 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (128239550..128275833, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (122474754..122511014, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (127212325..127248451, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene proline rich membrane anchor 1 Neighboring gene uncharacterized LOC120103607 Neighboring gene family with sequence similarity 181, member A Neighboring gene uncharacterized LOC102549032 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation. Bello NF, et al. Cell Death Differ, 2009 Jun. PMID 19300455, Free PMC Article
    2. ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. Kohroki J, et al. FEBS Lett, 2005 Dec 19. PMID 16325183
    3. Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Rajan S, et al. Physiol Genomics, 2012 Feb 1. PMID 22147266
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiac muscle cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiac muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dendritic cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart looping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in podosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal muscle atrophy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal muscle atrophy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 2
    Names
    ASB-2
    ankyrin repeat and SOCS box protein 2-like
    ankyrin repeat and SOCS box-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011984.1 → NP_001011984.1  ankyrin repeat and SOCS box protein 2

      See identical proteins and their annotated locations for NP_001011984.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085882
      UniProtKB/Swiss-Prot
      Q5U2S6
      UniProtKB/TrEMBL
      A6JEM4
      Related
      ENSRNOP00000071182.1, ENSRNOT00000085517.2
      Conserved Domains (4) summary
      cd00204
      Location:232 → 357
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03721
      Location:590 → 634
      SOCS_ASB2; SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been ...
      pfam12796
      Location:308 → 396
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:237 → 268
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      128239550..128275833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112072.2 → XP_038968000.1  ankyrin repeat and SOCS box protein 2 isoform X2

      Conserved Domains (3) summary
      PHA03095
      Location:199 → 480
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:237 → 268
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:112 → 202
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_063261766.1 → XP_063117836.1  ankyrin repeat and SOCS box protein 2 isoform X1

    3. XM_006240464.5 → XP_006240526.2  ankyrin repeat and SOCS box protein 2 isoform X3

    RNA

    1. XR_593075.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2S6.1 GenPept UniProtKB/Swiss-Prot:Q5U2S6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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