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    Anapc7 anaphase promoting complex subunit 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304490, updated on 2-May-2024

    Summary

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    Official Symbol
    Anapc7provided by RGD
    Official Full Name
    anaphase promoting complex subunit 7provided by RGD
    Primary source
    RGD:1311927
    See related
    Ensembl:ENSRNOG00000001283 AllianceGenome:RGD:1311927
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein phosphatase binding activity. Predicted to be involved in cell division; cellular protein metabolic process; and regulation of mitotic sister chromatid separation. Predicted to be located in nucleus and spindle. Predicted to be part of anaphase-promoting complex. Predicted to be active in cytoplasm. Orthologous to human ANAPC7 (anaphase promoting complex subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 84.4), Heart (RPKM 64.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Anapc7 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (39793518..39821614, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (34131214..34160819, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (39613898..39641999, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 81 Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Neighboring gene ribosomal protein L38, pseudogene 4 Neighboring gene uncharacterized LOC108352447 Neighboring gene small nucleolar RNA SNORA67 Neighboring gene actin related protein 2/3 complex, subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Mansfeld J, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926987, Free PMC Article
    2. Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Song MS, et al. Cell, 2011 Jan 21. PMID 21241890, Free PMC Article
    3. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Jin L, et al. Cell, 2008 May 16. PMID 18485873, Free PMC Article
    4. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Dube P, et al. Mol Cell, 2005 Dec 22. PMID 16364912
    5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    anaphase-promoting complex subunit 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107142.1 → NP_001100612.1  anaphase-promoting complex subunit 7

      See identical proteins and their annotated locations for NP_001100612.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/TrEMBL
      A0A8I6GMR3, A6J196, D3ZIT4
      Conserved Domains (2) summary
      TIGR02917
      Location:208 → 509
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:338 → 368
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      39793518..39821614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249365.4 → XP_006249427.2  anaphase-promoting complex subunit 7 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GMR3, A6J196, D3ZIT4
      Related
      ENSRNOP00000001729.3
      Conserved Domains (2) summary
      TIGR02917
      Location:208 → 509
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:338 → 368
      TPR; TPR repeat [structural motif]

    2. XM_039089466.2 → XP_038945394.1  anaphase-promoting complex subunit 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GMR3
      Conserved Domains (2) summary
      TIGR02917
      Location:141 → 442
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:271 → 301
      TPR; TPR repeat [structural motif]

    3. XM_017598334.3 → XP_017453823.1  anaphase-promoting complex subunit 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GMR3
      Related
      ENSRNOP00000097934.1
      Conserved Domains (2) summary
      TIGR02917
      Location:141 → 442
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:271 → 301
      TPR; TPR repeat [structural motif]

    4. XM_039089467.2 → XP_038945395.1  anaphase-promoting complex subunit 7 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GMR3
      Conserved Domains (2) summary
      TIGR02917
      Location:101 → 402
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:231 → 261
      TPR; TPR repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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