FABP2 fatty acid binding protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FABP2provided by HGNC
Official Full Name: fatty acid binding protein 2provided by HGNC
Primary source: HGNC:HGNC:3556
See related: Ensembl:ENSG00000145384 MIM:134640; AllianceGenome:HGNC:3556
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FABPI; I-FABP
Summary: The protein encoded by this gene is an intracellular fatty acid-binding protein that participates in the uptake, intracellular metabolism, and transport of long-chain fatty acids. The encoded protein is also involved in the modulation of cell growth and proliferation. This protein binds saturated long-chain fatty acids with high affinity, and may act as a lipid sensor to maintain energy homeostasis. [provided by RefSeq, Aug 2017]
Expression: Biased expression in small intestine (RPKM 287.0), duodenum (RPKM 142.3) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 4q26

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (119317250..119322138, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (122622352..122627246, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (120238405..120243293, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Ala54Thr polymorphism of the fatty acid transporter gene (FABP2) in patients with type 2 diabetes mellitus in Yakutia].
Title: [Ala54Thr polymorphism of the fatty acid transporter gene (FABP2) in patients with type 2 diabetes mellitus in Yakutia].
Genome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population.
Title: Genome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population.
Genetic polymorphism of fatty acid binding protein-2 in hyperlipidemic Asian Indians in North India.
Title: Genetic polymorphism of fatty acid binding protein-2 in hyperlipidemic Asian Indians in North India.
Gastric ultrasound, citrulline, and intestinal fatty acid-binding protein as markers of gastrointestinal dysfunction in critically ill patients: A pilot prospective cohort study.
Title: Gastric ultrasound, citrulline, and intestinal fatty acid-binding protein as markers of gastrointestinal dysfunction in critically ill patients: A pilot prospective cohort study.
Fatty acid binding protein 1 (FABP1) and fatty acid binding protein 2 (FABP2) as a link between diabetic nephropathy and subclinical atherosclerosis in children and adolescents with type 1 diabetes.
Title: Fatty acid binding protein 1 (FABP1) and fatty acid binding protein 2 (FABP2) as a link between diabetic nephropathy and subclinical atherosclerosis in children and adolescents with type 1 diabetes.
Serum Levels of IFABP2 and Differences in Lactobacillus and Porphyromonas gingivalis Abundance on Gut Microbiota Are Associated with Poor Therapeutic Response in Rheumatoid Arthritis: A Pilot Study.
Title: Serum Levels of IFABP2 and Differences in Lactobacillus and Porphyromonas gingivalis Abundance on Gut Microbiota Are Associated with Poor Therapeutic Response in Rheumatoid Arthritis: A Pilot Study.
Association between the FABP2 Ala54Thr and CRP+1059C/G polymorphisms and small dense LDL level in patients with atherosclerosis: a case-control study.
Title: Association between the FABP2 Ala54Thr and CRP+1059C/G polymorphisms and small dense LDL level in patients with atherosclerosis: a case-control study.
Increased intestinal-fatty acid binding protein in obesity-associated type 2 diabetes mellitus.
Title: Increased intestinal-fatty acid binding protein in obesity-associated type 2 diabetes mellitus.
Reduced circulating FABP2 in patients with moderate to severe COVID-19 may indicate enterocyte functional change rather than cell death.
Title: Reduced circulating FABP2 in patients with moderate to severe COVID-19 may indicate enterocyte functional change rather than cell death.
[Zonulin and I-FABP are markers of enterocyte damage in celiac disease].
Title: [Zonulin and I-FABP are markers of enterocyte damage in celiac disease].

Submit: New GeneRIF Correction See all GeneRIFs (148)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC31346P1 (e-PCR)
- UniSTS:272925

GDB:178665 (e-PCR)
- UniSTS:155038

SHGC4-8 (e-PCR)
- UniSTS:56501

NoName (e-PCR)
- UniSTS:483785

SHGC-59292 (e-PCR)
- UniSTS:49366

SHGC-145405 (e-PCR)
- UniSTS:174556

SHGC4-110 (e-PCR)
- UniSTS:88541

SHGC-59542 (e-PCR)
- UniSTS:47071

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables fatty acid binding	TAS Traceable Author Statement more info	PubMed
enables long-chain fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intestinal lipid absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical cortex	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in microvillus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fatty acid-binding protein, intestinal

Names: fatty acid binding protein 2, intestinal; intestinal-type fatty acid-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.