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    inx-3 Innexin-3 [ Caenorhabditis elegans ]

    Gene ID: 180866, updated on 12-Jun-2024

    Summary

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    Gene symbol
    inx-3
    Gene description
    Innexin-3
    Locus tag
    CELE_F22F4.2
    See related
    AllianceGenome:WB:WBGene00002125
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables actin filament binding activity and gap junction channel activity. Involved in embryonic morphogenesis and positive regulation of pharyngeal pumping. Located in cytoplasm and gap junction. Is expressed in several structures, including interfacial epithelial cell; muscle cell; neurons; pharynx; and rectum. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See inx-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    3
    Sequence:
    Chromosome: X; NC_003284.9 (5996156..5998243)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Kinesin-like protein Neighboring gene DUF4265 domain-containing protein Neighboring gene ncRNA Neighboring gene CC domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene SUppressor of Pkc-3 (pkc-3) Sterility

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans innexin INX-3 is localized to gap junctions and is essential for embryonic development. Starich TA, et al. Dev Biol, 2003 Apr 15. PMID 12679112
    2. Innexin-3 forms connexin-like intercellular channels. Landesman Y, et al. J Cell Sci, 1999 Jul. PMID 10381394
    3. NLR-1/CASPR Anchors F-Actin to Promote Gap Junction Formation. Meng L, et al. Dev Cell, 2020 Dec 7. PMID 33238150, Free PMC Article
    4. Innexins: members of an evolutionarily conserved family of gap-junction proteins. Phelan P. Biochim Biophys Acta, 2005 Jun 10. PMID 15921654
    5. The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells. Barnes TM, et al. J Neurochem, 1997 Dec. PMID 9375655

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gap junction channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables gap junction channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables gap junction hemi-channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in gap junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Innexin-3
    NP_509002.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5996156..5998243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076601.7 → NP_509002.2  Innexin-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509002.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17393, Q19746
      Conserved Domains (1) summary
      pfam00876
      Location:21 → 370
      Innexin; Innexin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19746.2

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