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    ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 6482, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ST3GAL1provided by HGNC
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:10862
    See related
    Ensembl:ENSG00000008513 MIM:607187; AllianceGenome:HGNC:10862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ST3O; SIAT4A; SIATFL; ST3GalA; ST3GalIA; Gal-NAc6S; ST3GalA.1; ST3GalIA,1
    Summary
    The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in thyroid (RPKM 30.7), kidney (RPKM 13.0) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ST3GAL1 in Genome Data Viewer
    Location:
    8q24.22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (133454848..133571887, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (134578690..134699857, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (134467091..134584130, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:134420089-134420640 Neighboring gene DPPA3 pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:134434961-134435460 Neighboring gene ST13, Hsp70 interacting protein pseudogene 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:134461533-134461691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19563 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:134465210-134465710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:134465711-134466211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27996 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:134500724-134501507 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:134502985-134503530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28000 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:134512049-134512574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:134513872-134514372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19564 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_101228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28003 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:134544558-134545408 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_101271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:134581917-134582770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19566 Neighboring gene ST3GAL1 divergent transcript Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_101278 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:134643666-134643864 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene long intergenic non-protein coding RNA 3024

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer. Lin WD, et al. Cancer Immunol Res, 2021 Jan. PMID 33177111
    2. Structural and functional role of disulphide bonds and substrate binding residues of the human beta-galactoside alpha-2,3-sialyltransferase 1 (hST3Gal1). Ortiz-Soto ME, et al. Sci Rep, 2019 Nov 29. PMID 31784620, Free PMC Article
    3. α2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells. Wen KC, et al. Oncotarget, 2017 Apr 25. PMID 28423672, Free PMC Article
    4. ST3GAL1-Associated Transcriptomic Program in Glioblastoma Tumor Growth, Invasion, and Prognosis. Chong YK, et al. J Natl Cancer Inst, 2016 Feb. PMID 26547933, Free PMC Article
    5. Siaα2-3Galβ1- Receptor Genetic Variants Are Associated with Influenza A(H1N1)pdm09 Severity. Maestri A, et al. PLoS One, 2015. PMID 26436774, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation.
      Title: Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation.
    2. Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer.
      Title: Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer.
    3. ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL.
      Title: ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL.
    4. Structural and functional role of disulphide bonds and substrate binding residues of the human beta-galactoside alpha-2,3-sialyltransferase 1 (hST3Gal1).
      Title: Structural and functional role of disulphide bonds and substrate binding residues of the human beta-galactoside alpha-2,3-sialyltransferase 1 (hST3Gal1).
    5. ST3GAL1 promotes cell migration, invasion, and TGFB1-induced epithelial-mesenchymal transition and confers paclitaxel resistance in ovarian cancer.
      Title: Sialyltransferase ST3GAL1 promotes cell migration, invasion, and TGF-β1-induced EMT and confers paclitaxel resistance in ovarian cancer.
    6. Data suggest that GDNF family receptor alpha 1 protein (GFRA1) is a protein target of ST3 beta-galactoside alpha-23-sialyltransferase 1 (ST3GAL1).
      Title: Reciprocal feedback regulation of ST3GAL1 and GFRA1 signaling in breast cancer cells.
    7. Expression levels of ST3Gal1 and TGFB1 were high in breast cancer tumors samples and positively correlated with each other. Shorter relapse-free survival associated with lower expression of VASN and combination of low VASN with high ST3GAL1 yielded even higher risk of recurrence. Findings illustrated a feedback regulatory loop in which TGF-beta1 upregulates ST3Gal1 to circumvent the negative impact of VASN.
      Title: Sialylation of vasorin by ST3Gal1 facilitates TGF-β1-mediated tumor angiogenesis and progression.
    8. Study demonstrates that ST3GalI regulates ovarian cancer cell migration and peritoneal dissemination via EGFR signaling.
      Title: α2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells.
    9. ST3Gal I and ST6Gal I have different sialic acid donor specificity.
      Title: Probing the CMP-Sialic Acid Donor Specificity of Two Human β-d-Galactoside Sialyltransferases (ST3Gal I and ST6Gal I) Selectively Acting on O- and N-Glycosylproteins.
    10. Describe differential expression profiles of alpha-2, 3-sialyltransferases (ST) and miR-4701-5p in three pairs of chronic myeloid leukemia (CML) cell lines and 48 clinical samples of bone marrow mononuclear cells from CML patients. miR-4701-5p directly targeted ST3GAL1 to reduce CML cells resistance to multiple chemotherapeutics in vitro.
      Title: Alpha-2, 3-sialyltransferases regulate the multidrug resistance of chronic myeloid leukemia through miR-4701-5p targeting ST3GAL1.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.
    EBI GWAS Catalog
    Genome-wide association study and meta-analysis of intraocular pressure.
    EBI GWAS Catalog
    Genome-wide association study of the five-factor model of personality in young Korean women.
    EBI GWAS Catalog
    Genome-wide association study to characterize serum bilirubin elevations in patients with HCV treated with GS-9256, an HCV NS3 serine protease inhibitor.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC9183, FLJ36548, DKFZp666E036, DKFZp779K2051

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables sialyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylneuraminate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in O-glycan processing TAS
    Traceable Author Statement
    more info
    		  
    involved_in ganglioside biosynthetic process via lactosylceramide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ganglioside biosynthetic process via lactosylceramide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in keratan sulfate biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in memory B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein sialylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sialylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sialylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in viral protein processing TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi medial cisterna membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in Golgi trans cisterna membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
    Names
    Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
    SIAT4-A
    ST3GalI
    alpha 2,3-ST 1
    beta-galactoside alpha-2,3-sialyltransferase 1
    monosialoganglioside sialyltransferase
    sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase)
    sialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase)
    sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase)
    NP_003024.1
    NP_775479.1
    XP_005251082.1
    XP_006716680.1
    XP_016869225.1
    XP_047278061.1
    XP_047278062.1
    XP_054216992.1
    XP_054216993.1
    XP_054216994.1
    XP_054216995.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003033.4 → NP_003024.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

      See identical proteins and their annotated locations for NP_003024.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF186191, BC018357, BX648001
      Consensus CDS
      CCDS6373.1
      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51
      Related
      ENSP00000428540.1, ENST00000521180.5
      Conserved Domains (1) summary
      pfam00777
      Location:83 → 338
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. NM_173344.3 → NP_775479.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

      See identical proteins and their annotated locations for NP_775479.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF059321, AF186191, BC018357, BX648001, CN359425
      Consensus CDS
      CCDS6373.1
      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51
      Related
      ENSP00000430515.1, ENST00000522652.6
      Conserved Domains (1) summary
      pfam00777
      Location:83 → 338
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      133454848..133571887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013736.3 → XP_016869225.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51
      Conserved Domains (1) summary
      pfam00777
      Location:83 → 338
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_006716617.3 → XP_006716680.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006716680.1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51
      Related
      ENSP00000497381.1, ENST00000648219.1
      Conserved Domains (1) summary
      pfam00777
      Location:83 → 338
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. XM_047422106.1 → XP_047278062.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51

    4. XM_047422105.1 → XP_047278061.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51

    5. XM_005251025.6 → XP_005251082.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_005251082.1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51
      Conserved Domains (1) summary
      pfam00777
      Location:83 → 338
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      134578690..134699857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361018.1 → XP_054216993.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51

    2. XM_054361017.1 → XP_054216992.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51

    3. XM_054361020.1 → XP_054216995.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51

    4. XM_054361019.1 → XP_054216994.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q11201.1 GenPept UniProtKB/Swiss-Prot:Q11201

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