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    Galnt10 polypeptide N-acetylgalactosaminyltransferase 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170501, updated on 13-Apr-2024

    Summary

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    Symbol
    Galnt10provided by RGD
    Full Name
    polypeptide N-acetylgalactosaminyltransferase 10provided by RGD
    Primary source
    RGD:69409
    See related
    Ensembl:ENSRNOG00000002488 AllianceGenome:RGD:69409
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Galnt9
    Summary
    Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in O-glycan processing. Predicted to act upstream of or within protein O-linked glycosylation. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Orthologous to human GALNT10 (polypeptide N-acetylgalactosaminyltransferase 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 292.2), Spleen (RPKM 146.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Galnt10 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (42321691..42468087)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (41821216..41967618)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (43067316..43208992)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor AMPA type subunit 1 Neighboring gene uncharacterized LOC120095106 Neighboring gene family with sequence similarity 114, member A2 Neighboring gene microfibril associated protein 3 Neighboring gene uncharacterized LOC134480689 Neighboring gene SAP30-like Neighboring gene heart and neural crest derivatives expressed 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection. Raman J, et al. J Biol Chem, 2008 Aug 22. PMID 18562306, Free PMC Article
    2. Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10. Cheng L, et al. FEBS Lett, 2002 Nov 6. PMID 12417297
    3. Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2. Perrine CL, et al. J Biol Chem, 2009 Jul 24. PMID 19460755, Free PMC Article
    4. Cloning and characterization of a ninth member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, ppGaNTase-T9. Ten Hagen KG, et al. J Biol Chem, 2001 May 18. PMID 11278534
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in O-glycan processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in O-glycan processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 10
    Names
    GalNAc-T9
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10
    UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 9
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
    galNAc-T10
    polypeptide GalNAc transferase 10
    pp-GaNTase 10
    protein-UDP acetylgalactosaminyltransferase 10
    NP_570098.1
    XP_038941033.1
    XP_038941034.1
    XP_038941035.1
    XP_038941037.1
    XP_038941038.1
    XP_063124427.1
    XP_063124428.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130742.2 → NP_570098.1  polypeptide N-acetylgalactosaminyltransferase 10

      See identical proteins and their annotated locations for NP_570098.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q925R7
      UniProtKB/TrEMBL
      A0A8L2Q1N1, A6HEP7
      Related
      ENSRNOP00000003447.2, ENSRNOT00000003447.4
      Conserved Domains (4) summary
      cd02510
      Location:148 → 443
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG1216
      Location:145 → 449
      GT2; Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism]
      cd00161
      Location:461 → 589
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:459 → 587
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      42321691..42468087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085107.2 → XP_038941035.1  polypeptide N-acetylgalactosaminyltransferase 10 isoform X3

      Conserved Domains (1) summary
      cl11394
      Location:297 → 501
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. XM_039085109.2 → XP_038941037.1  polypeptide N-acetylgalactosaminyltransferase 10 isoform X4

      Conserved Domains (1) summary
      cl11394
      Location:297 → 501
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    3. XM_039085110.2 → XP_038941038.1  polypeptide N-acetylgalactosaminyltransferase 10 isoform X5

      Conserved Domains (1) summary
      cl11394
      Location:297 → 501
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    4. XM_039085106.2 → XP_038941034.1  polypeptide N-acetylgalactosaminyltransferase 10 isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q1N1
      Conserved Domains (2) summary
      cd02510
      Location:297 → 592
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:610 → 686
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    5. XM_039085105.2 → XP_038941033.1  polypeptide N-acetylgalactosaminyltransferase 10 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q1N1
      Conserved Domains (2) summary
      cd02510
      Location:297 → 592
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:608 → 736
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    6. XM_063268357.1 → XP_063124427.1  polypeptide N-acetylgalactosaminyltransferase 10 isoform X6

    7. XM_063268358.1 → XP_063124428.1  polypeptide N-acetylgalactosaminyltransferase 10 isoform X7

    RNA

    1. XR_010055122.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q925R7.1 GenPept UniProtKB/Swiss-Prot:Q925R7

    Gene LinkOut

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