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    GSTT4 glutathione S-transferase theta 4 [ Homo sapiens (human) ]

    Gene ID: 25774, updated on 11-Apr-2024

    Summary

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    Official Symbol
    GSTT4provided by HGNC
    Official Full Name
    glutathione S-transferase theta 4provided by HGNC
    Primary source
    HGNC:HGNC:26930
    See related
    Ensembl:ENSG00000276950 AllianceGenome:HGNC:26930
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GSTTP1; HS322B1A
    Summary
    Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 4.0) See more
    Orthologs
    all
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    Genomic context

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    Location:
    22q11.23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (23989115..24005453, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (24405779..24412527, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24340595..24347350, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene D-dopachrome tautomerase like Neighboring gene D-dopachrome tautomerase Neighboring gene glutathione S-transferase theta 2 (gene/pseudogene) Neighboring gene uncharacterized LOC105372959 Neighboring gene calcineurin binding protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24487229-24487730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24487731-24488230 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24527017-24527518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24540118-24540852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24540853-24541588 Neighboring gene Sharpr-MPRA regulatory region 1007 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18761 Neighboring gene skeletal muscle cis-regulatory module in CABIN1 intron Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24571075-24571934

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genetic polymorphism of glutathione S-transferase P1 gene and lung cancer risk. To-Figueras J, et al. Cancer Causes Control, 1999 Feb. PMID 10334644
    2. The DNA sequence of human chromosome 22. Dunham I, et al. Nature, 1999 Dec 2. PMID 10591208
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119755, MGC119756

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase theta-4
    Names
    GST class-theta-4
    glutathione S-transferase theta pseudogene 1
    NP_001345593.1
    XP_024307967.1
    XP_024307968.1
    XP_024307970.1
    XP_054181452.1
    XP_054181453.1
    XP_054181454.1
    XP_054185427.1
    XP_054185428.1
    XP_054185429.1
    XP_054185430.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358664.2 → NP_001345593.1  glutathione S-transferase theta-4

      Status: VALIDATED

      Source sequence(s)
      AC253536
      Consensus CDS
      CCDS87011.1
      UniProtKB/Swiss-Prot
      A0A1W2PR19
      UniProtKB/TrEMBL
      A0A1W2PQM5
      Related
      ENSP00000492273.1, ENST00000621179.6
      Conserved Domains (2) summary
      cd03183
      Location:91 → 217
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      cl00388
      Location:3 → 78
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RNA

    1. NR_003081.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC253536
      Related
      ENST00000611600.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      23989115..24005453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024452202.2 → XP_024307970.1  glutathione S-transferase theta-4 isoform X3

      Conserved Domains (2) summary
      cl00388
      Location:7 → 81
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl02776
      Location:100 → 157
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. XM_024452199.2 → XP_024307967.1  glutathione S-transferase theta-4 isoform X1

      Conserved Domains (2) summary
      cl00388
      Location:7 → 81
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl02776
      Location:100 → 198
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    3. XM_024452200.2 → XP_024307968.1  glutathione S-transferase theta-4 isoform X2

      Conserved Domains (2) summary
      cl00388
      Location:32 → 71
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl02776
      Location:90 → 188
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187633.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      224697..241525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329455.1 → XP_054185430.1  glutathione S-transferase theta-4 isoform X6

    2. XM_054329452.1 → XP_054185427.1  glutathione S-transferase theta-4 isoform X4

    3. XM_054329454.1 → XP_054185429.1  glutathione S-transferase theta-4 isoform X5

    4. XM_054329453.1 → XP_054185428.1  glutathione S-transferase theta-4 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      24405779..24412527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325477.1 → XP_054181452.1  glutathione S-transferase theta-4 isoform X7

    2. XM_054325479.1 → XP_054181454.1  glutathione S-transferase theta-4 isoform X8

    3. XM_054325478.1 → XP_054181453.1  glutathione S-transferase theta-4 isoform X8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001039498.1: Suppressed sequence

      Description
      NM_001039498.1: This RefSeq was permanently suppressed because we now believe this locus is a pseudogene rather than a protein-coding gene.

    2. NM_001040638.1: Suppressed sequence

      Description
      NM_001040638.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

    3. NM_015371.1: Suppressed sequence

      Description
      NM_015371.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidiate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A1W2PR19.1 GenPept UniProtKB/Swiss-Prot:A0A1W2PR19

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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