U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ZDHHC1 zinc finger DHHC-type containing 1 [ Homo sapiens (human) ]

    Gene ID: 29800, updated on 7-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ZDHHC1provided by HGNC
    Official Full Name
    zinc finger DHHC-type containing 1provided by HGNC
    Primary source
    HGNC:HGNC:17916
    See related
    Ensembl:ENSG00000159714 AllianceGenome:HGNC:17916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DHHC-1; ZNF377; C16orf1; HSU90653
    Summary
    Enables palmitoyltransferase activity. Involved in antiviral innate immune response; positive regulation of defense response to virus by host; and protein palmitoylation. Located in Golgi apparatus and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary (RPKM 6.2), testis (RPKM 6.1) and 24 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    16q22.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67394152..67416477, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73188923..73211253, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67428055..67450380, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7602 Neighboring gene leucine rich repeat containing 36 Neighboring gene RNA, U1 small nuclear 123, pseudogene Neighboring gene tubulin polymerization promoting protein family member 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67439721-67440606 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67440607-67441493 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67441494-67442379 Neighboring gene uncharacterized LOC124903702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67450269-67450926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67454837-67455408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67458128-67458722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67461918-67462452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67462453-67462987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7605 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67469389-67469890 Neighboring gene hydroxysteroid 11-beta dehydrogenase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67477413-67478036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67478661-67479284 Neighboring gene ATPase H+ transporting V0 subunit d1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67481159-67481658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67485489-67486172 Neighboring gene Sharpr-MPRA regulatory region 10086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67495532-67496032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67499338-67499838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67499839-67500339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10966

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and pyroptosis. Le X, et al. Theranostics, 2020. PMID 32863941, Free PMC Article
    2. The DHHC domain: a new highly conserved cysteine-rich motif. Putilina T, et al. Mol Cell Biochem, 1999 May. PMID 10395086
    3. p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication. Wang X, et al. PLoS Pathog, 2020 Oct. PMID 33108395, Free PMC Article
    4. The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. Zhou Q, et al. Cell Host Microbe, 2014 Oct 8. PMID 25299331
    5. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. Oku S, et al. J Biol Chem, 2013 Jul 5. PMID 23687301, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and pyroptosis.
      Title: DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and pyroptosis.
    2. p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication.
      Title: p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication.
    3. In an expression screen for proteins that can activate the IFNB1 promoter, authors identified the ER-associated protein ZDHHC1 as a positive regulator of virus-triggered, MITA/STING-dependent immune signaling.
      Title: The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling.
    4. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
      Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
    5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide searching of rare genetic variants in WTCCC data.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-L-cysteine S-palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    palmitoyltransferase ZDHHC1
    Names
    DHHC domain-containing cysteine-rich protein 1
    probable palmitoyltransferase ZDHHC1
    zinc finger DHHC domain-containing protein 1
    zinc finger protein 377
    zinc finger, DHHC domain containing 1
    NP_001310556.1
    NP_037436.1
    XP_006721248.1
    XP_011521362.1
    XP_024306013.1
    XP_024306014.1
    XP_024306015.1
    XP_054236159.1
    XP_054236160.1
    XP_054236161.1
    XP_054236162.1
    XP_054236163.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001323627.2 → NP_001310556.1  palmitoyltransferase ZDHHC1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009061, BM724650, BX111231, HY054038, U90653
      Consensus CDS
      CCDS92175.1
      UniProtKB/TrEMBL
      I3L202
      Related
      ENSP00000459264.2, ENST00000565726.3
      Conserved Domains (1) summary
      pfam01529
      Location:129 → 284
      zf-DHHC; DHHC palmitoyltransferase

    2. NM_013304.3 → NP_037436.1  palmitoyltransferase ZDHHC1 isoform 1

      See identical proteins and their annotated locations for NP_037436.1

      Status: VALIDATED

      Source sequence(s)
      AC009061, BC021908, CA432496, U90653
      Consensus CDS
      CCDS10836.1
      UniProtKB/Swiss-Prot
      O15461, Q8WTX9
      Related
      ENSP00000340299.2, ENST00000348579.6
      Conserved Domains (1) summary
      pfam01529
      Location:129 → 284
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      67394152..67416477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450247.2 → XP_024306015.1  palmitoyltransferase ZDHHC1 isoform X4

      Conserved Domains (1) summary
      pfam01529
      Location:129 → 284
      zf-DHHC; DHHC palmitoyltransferase

    2. XM_024450246.2 → XP_024306014.1  palmitoyltransferase ZDHHC1 isoform X3

      Conserved Domains (2) summary
      pfam01529
      Location:129 → 284
      zf-DHHC; DHHC palmitoyltransferase
      pfam03546
      Location:323 → 469
      Treacle; Treacher Collins syndrome protein Treacle

    3. XM_006721185.3 → XP_006721248.1  palmitoyltransferase ZDHHC1 isoform X2

      Conserved Domains (1) summary
      pfam01529
      Location:129 → 284
      zf-DHHC; DHHC palmitoyltransferase

    4. XM_024450245.2 → XP_024306013.1  palmitoyltransferase ZDHHC1 isoform X1

      UniProtKB/Swiss-Prot
      O15461, Q8WTX9
      Conserved Domains (1) summary
      pfam01529
      Location:129 → 284
      zf-DHHC; DHHC palmitoyltransferase

    5. XM_011523060.2 → XP_011521362.1  palmitoyltransferase ZDHHC1 isoform X5

      Conserved Domains (1) summary
      pfam01529
      Location:44 → 199
      zf-DHHC; DHHC palmitoyltransferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      73188923..73211253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380187.1 → XP_054236162.1  palmitoyltransferase ZDHHC1 isoform X4

    2. XM_054380186.1 → XP_054236161.1  palmitoyltransferase ZDHHC1 isoform X3

    3. XM_054380185.1 → XP_054236160.1  palmitoyltransferase ZDHHC1 isoform X2

    4. XM_054380184.1 → XP_054236159.1  palmitoyltransferase ZDHHC1 isoform X1

      UniProtKB/Swiss-Prot
      O15461, Q8WTX9

    5. XM_054380188.1 → XP_054236163.1  palmitoyltransferase ZDHHC1 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WTX9.1 GenPept UniProtKB/Swiss-Prot:Q8WTX9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous