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    Fxyd5 FXYD domain-containing ion transport regulator 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60338, updated on 2-May-2024

    Summary

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    Official Symbol
    Fxyd5provided by RGD
    Official Full Name
    FXYD domain-containing ion transport regulator 5provided by RGD
    Primary source
    RGD:620827
    See related
    Ensembl:ENSRNOG00000021062 AllianceGenome:RGD:620827
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RIC
    Summary
    This reference sequence was derived from multiple replicate ESTs and validated by similar mouse cDNA sequence and human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Three transcript variants encoding the same protein have been found for this gene. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000]
    Expression
    Biased expression in Thymus (RPKM 194.2), Spleen (RPKM 183.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fxyd5 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95395327..95404722, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86267937..86277329, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89464853..89474450, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 187, member B Neighboring gene uncharacterized LOC134483094 Neighboring gene uncharacterized LOC134483095 Neighboring gene FXYD domain-containing ion transport regulator 7 Neighboring gene FXYD domain-containing ion transport regulator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Reduced expression of FXYD domain containing ion transport regulator 5 in association with hypertension. Huang X, et al. Int J Mol Med, 2012 Feb. PMID 22085977
    2. Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis. Ino Y, et al. Proc Natl Acad Sci U S A, 2002 Jan 8. PMID 11756660, Free PMC Article
    3. FXYD domain containing ion transport regulator 5 (FXYD5) silencing promotes cell viability and alleviates inflammatory response in cerulein-induced AR42J cells by blocking JAK2/STAT3 signaling pathway. Ding L, et al. Bioengineered, 2022 Feb. PMID 35042436, Free PMC Article
    4. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Sweadner KJ, et al. Genomics, 2000 Aug 15. PMID 10950925
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FXYD domain containing ion transport regulator 5 (FXYD5) silencing promotes cell viability and alleviates inflammatory response in cerulein-induced AR42J cells by blocking JAK2/STAT3 signaling pathway.
      Title: FXYD domain containing ion transport regulator 5 (FXYD5) silencing promotes cell viability and alleviates inflammatory response in cerulein-induced AR42J cells by blocking JAK2/STAT3 signaling pathway.
    2. FXYD5 may have profound impact on the regulation of blood pressure.
      Title: Reduced expression of FXYD domain containing ion transport regulator 5 in association with hypertension.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cadherin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ion channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ion channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of sodium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    FXYD domain-containing ion transport regulator 5
    Names
    oncoprotein induced transcript 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270688.1 → NP_001257617.1  FXYD domain-containing ion transport regulator 5 precursor

      See identical proteins and their annotated locations for NP_001257617.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      DV726876, FM112735, FM122563, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P59647, Q6P9W0
      UniProtKB/TrEMBL
      A0A8I6A4C9, A6JA47
      Related
      ENSRNOP00000068919.2, ENSRNOT00000089474.2
      Conserved Domains (1) summary
      pfam02038
      Location:130 → 171
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

    2. NM_001270689.1 → NP_001257618.1  FXYD domain-containing ion transport regulator 5 precursor

      See identical proteins and their annotated locations for NP_001257618.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      DV726876, FM122563, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P59647, Q6P9W0
      UniProtKB/TrEMBL
      A0A8I6A4C9, A6JA47
      Conserved Domains (1) summary
      pfam02038
      Location:130 → 171
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

    3. NM_021909.2 → NP_068709.2  FXYD domain-containing ion transport regulator 5 precursor

      See identical proteins and their annotated locations for NP_068709.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      DV726876, FM112735, FM122563, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P59647, Q6P9W0
      UniProtKB/TrEMBL
      A0A8I6A4C9, A6JA47
      Related
      ENSRNOP00000085788.1, ENSRNOT00000117579.1
      Conserved Domains (1) summary
      pfam02038
      Location:130 → 171
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      95395327..95404722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272422.1 → XP_063128492.1  FXYD domain-containing ion transport regulator 5 isoform X1

      UniProtKB/TrEMBL
      A0A8L2R1T4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59647.2 GenPept UniProtKB/Swiss-Prot:P59647

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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