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    Zfp961 zinc finger protein 961 [ Mus musculus (house mouse) ]

    Gene ID: 234413, updated on 12-May-2024

    Summary

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    Official Symbol
    Zfp961provided by MGI
    Official Full Name
    zinc finger protein 961provided by MGI
    Primary source
    MGI:MGI:3583954
    See related
    Ensembl:ENSMUSG00000052446 AllianceGenome:MGI:3583954
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mszf37; BC065788; mszf55-2; A230105L22Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Orthologous to human ZNF101 (zinc finger protein 101). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.9), bladder adult (RPKM 6.1) and 28 other tissues See more
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    Genomic context

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    See Zfp961 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.63 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72704910..72724177)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71951048..71970333)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 882 Neighboring gene STARR-positive B cell enhancer ABC_E10511 Neighboring gene cyclin B2, pseudogene Neighboring gene zinc finger protein 617 Neighboring gene STARR-positive B cell enhancer ABC_E3784 Neighboring gene STARR-seq mESC enhancer starr_21836 Neighboring gene STARR-seq mESC enhancer starr_21837 Neighboring gene STARR-seq mESC enhancer starr_21838 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 18 Neighboring gene predicted gene, 51535 Neighboring gene predicted gene 45734

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The KRAB Domain-Containing Protein ZFP961 Represses Adipose Thermogenesis and Energy Expenditure through Interaction with PPARα. Huang L, et al. Adv Sci (Weinh), 2022 Jan. PMID 34747141, Free PMC Article
    2. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    3. Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J. Timmermans S, et al. JCI Insight, 2018 Jul 12. PMID 29997285, Free PMC Article
    4. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC234413

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164581.1 → NP_001158053.1  uncharacterized protein LOC234413

      Status: VALIDATED

      Source sequence(s)
      AC164531
      Consensus CDS
      CCDS52591.1
      UniProtKB/TrEMBL
      E9Q4R5
      Related
      ENSMUSP00000105623.3, ENSMUST00000109997.10
      Conserved Domains (6) summary
      smart00349
      Location:25 → 65
      KRAB; krueppel associated box
      COG5048
      Location:280 → 439
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:340 → 360
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:25 → 64
      KRAB; KRAB box
      pfam13465
      Location:380 → 405
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      72704910..72724177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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