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    Zfp111 zinc finger protein 111 [ Mus musculus (house mouse) ]

    Gene ID: 56707, updated on 12-May-2024

    Summary

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    Official Symbol
    Zfp111provided by MGI
    Official Full Name
    zinc finger protein 111provided by MGI
    Primary source
    MGI:MGI:1929114
    See related
    Ensembl:ENSMUSG00000087598 AllianceGenome:MGI:1929114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription, DNA-templated. Located in nucleus. Is expressed in early conceptus; genitourinary system; and gut. Orthologous to human ZNF235 (zinc finger protein 235). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Zfp111 in Genome Data Viewer
    Location:
    7 A3; 7 10.27 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (23890760..23907574, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24193215..24208149, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2817 Neighboring gene zinc finger protein 235 Neighboring gene STARR-seq mESC enhancer starr_18251 Neighboring gene zinc finger protein 114 Neighboring gene zinc finger protein 109 Neighboring gene zinc finger protein 108

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role for a Zinc Finger Protein (Zfp111) in Transformation of 208F Rat Fibroblasts by Jaagsiekte Sheep Retrovirus Envelope Protein. Hsu T, et al. J Virol, 2015 Oct. PMID 26246563, Free PMC Article
    2. Identification and characterization of reproductive KRAB-ZF genes in mice. Jin S, et al. Gene, 2015 Jul 1. PMID 25827285
    3. Multidimensional genome scans identify the combinations of genetic loci linked to diabetes-related phenotypes in mice. Togawa K, et al. Hum Mol Genet, 2006 Jan 1. PMID 16321990
    4. Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice. Michaud EJ, et al. BMC Genomics, 2005 Nov 21. PMID 16300676, Free PMC Article
    5. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel cellular protein, Zfp111, binds to the JSRV Env protein, and this binding plays a role in retroviral transformation.
      Title: Role for a Zinc Finger Protein (Zfp111) in Transformation of 208F Rat Fibroblasts by Jaagsiekte Sheep Retrovirus Envelope Protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (1) 
    • Targeted (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 111

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310670.1 → NP_001297599.1  zinc finger protein 111 isoform 2

      See identical proteins and their annotated locations for NP_001297599.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two 5' exons and its 5' terminal exon begins before a splice site that is used in variant 1. This results in a novel 5' coding region and 5' UTR, compared to variant 1. It encodes isoform 2 which has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC138791, BB618616, BP758385, BU056699
      Consensus CDS
      CCDS80674.1
      UniProtKB/TrEMBL
      Q9R164
      Related
      ENSMUSP00000129484.2, ENSMUST00000056683.3
      Conserved Domains (5) summary
      smart00349
      Location:9 → 58
      KRAB; krueppel associated box
      COG5048
      Location:210 → 619
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:575 → 595
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:9 → 48
      KRAB; KRAB box
      pfam13465
      Location:615 → 640
      zf-H2C2_2; Zinc-finger double domain

    2. NM_019940.2 → NP_064324.2  zinc finger protein 111 isoform 1

      See identical proteins and their annotated locations for NP_064324.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
      Source sequence(s)
      AC138791, AF167318, AK045800, BB618616
      Consensus CDS
      CCDS20944.2
      UniProtKB/TrEMBL
      Q99K53
      Related
      ENSMUSP00000083169.6, ENSMUST00000086006.12
      Conserved Domains (5) summary
      smart00349
      Location:8 → 57
      KRAB; krueppel associated box
      COG5048
      Location:209 → 618
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:574 → 594
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:614 → 639
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      23890760..23907574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242815.2 → XP_030098675.1  zinc finger protein 111 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:377 → 672
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:605 → 625
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:39 → 79
      KRAB; KRAB box
      pfam13465
      Location:674 → 696
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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