hspa5 heat shock protein 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hspa5provided by ZNC
Official Full Name: heat shock protein 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-031001-11
See related: Ensembl:ENSDARG00000103846 AllianceGenome:ZFIN:ZDB-GENE-031001-11
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb865; fb60h09; fi36d04; zgc:55994; zgc:77606; wu:fb60h09; wu:fi36d04
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Acts upstream of or within response to hypoxia and response to yeast. Located in extracellular region. Is expressed in several structures, including central nervous system; digestive system; immature eye; prechordal plate; and sensory system. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (2713778..2721686, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (2440679..2448587)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphatidylinositol deficient zebrafish have elevated hspa5 expression in the liver and hepatic lipid accumulation due to endoplasmic reticulum stress response.
Title: Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fb60h09.x1 (e-PCR)
- UniSTS:203376

fb61g10.x1 (e-PCR)
- UniSTS:190878

fd59b06.y1 (e-PCR)
- UniSTS:195745

AW175535 (e-PCR)
- UniSTS:205769

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to yeast	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
part_of endoplasmic reticulum chaperone complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum lumen	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: endoplasmic reticulum chaperone BiP

Names: bip; glucose-regulated protein, 78kDa; heat shock 70kDa protein 5 (glucose-regulated protein)

NP_998223.1

EC 3.6.4.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213058.1 → NP_998223.1 endoplasmic reticulum chaperone BiP precursor

See identical proteins and their annotated locations for NP_998223.1

Status: PROVISIONAL

Source sequence(s)

BC052971

UniProtKB/TrEMBL

Q7SZD3

Related

ENSDARP00000131952.1, ENSDART00000169404.3

Conserved Domains (3) summary

cd10241
Location:26 → 401

HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins

PTZ00009
Location:29 → 641

PTZ00009; heat shock 70 kDa protein; Provisional

cl21456
Location:583 → 640

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily