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    Maco1 macoilin 1 [ Mus musculus (house mouse) ]

    Gene ID: 66146, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Maco1provided by MGI
    Official Full Name
    macoilin 1provided by MGI
    Primary source
    MGI:MGI:1913396
    See related
    Ensembl:ENSMUSG00000028826 AllianceGenome:MGI:1913396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C61; Tmem57; 1110007C24Rik; 9230118A01Rik
    Summary
    Predicted to enable microtubule binding activity. Acts upstream of or within brain development. Located in several cellular components, including axon; neuron projection terminus; and nuclear membrane. Orthologous to human MACO1 (macoilin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 14.9), CNS E18 (RPKM 14.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D3; 4 67.11 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134530070..134581242, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134802759..134853931, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene mannosidase, alpha, class 1C, member 1 Neighboring gene predicted gene, 42326 Neighboring gene STARR-seq mESC enhancer starr_11682 Neighboring gene STARR-seq mESC enhancer starr_11683 Neighboring gene STARR-positive B cell enhancer ABC_E9086 Neighboring gene STARR-positive B cell enhancer ABC_E10265 Neighboring gene low density lipoprotein receptor adaptor protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E3527 Neighboring gene STARR-seq mESC enhancer starr_11687 Neighboring gene STARR-seq mESC enhancer starr_11688 Neighboring gene STARR-positive B cell enhancer ABC_E2718 Neighboring gene STARR-positive B cell enhancer ABC_E4682 Neighboring gene STARR-seq mESC enhancer starr_11693 Neighboring gene Rh blood group, D antigen Neighboring gene transmembrane protein 50A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Entire sequence of a mouse chromosomal segment containing the gene Rhced and a comparative analysis of the homologous human sequence. Kumada M, et al. Gene, 2002 Oct 16. PMID 12459264
    2. Identification of a novel brain-specific and Reelin-regulated gene that encodes a protein colocalized with synapsin. Kuvbachieva A, et al. Eur J Neurosci, 2004 Aug. PMID 15255972
    3. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Georgas K, et al. Dev Biol, 2009 Aug 15. PMID 19501082
    4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuronal signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuronal signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in rough endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in rough endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    macoilin
    Names
    brain-specific adapter protein C61
    brain-specific adaptor protein C61
    transmembrane protein 57

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355499.1 → NP_001342428.1  macoilin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK038972, AY846873
      UniProtKB/TrEMBL
      Q80YA4
      Conserved Domains (1) summary
      pfam09726
      Location:19 → 606
      Macoilin; Transmembrane protein

    2. NM_001355500.1 → NP_001342429.1  macoilin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AY846873
      UniProtKB/TrEMBL
      Q80YA4
      Conserved Domains (1) summary
      pfam09726
      Location:1 → 485
      Macoilin; Transmembrane protein

    3. NM_001355501.1 → NP_001342430.1  macoilin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AY846873
      UniProtKB/TrEMBL
      Q80YA4
      Conserved Domains (1) summary
      pfam09726
      Location:1 → 485
      Macoilin; Transmembrane protein

    4. NM_025382.6 → NP_079658.2  macoilin isoform 1

      See identical proteins and their annotated locations for NP_079658.2

      Status: VALIDATED

      Source sequence(s)
      AY846873
      Consensus CDS
      CCDS18777.1
      UniProtKB/Swiss-Prot
      Q7TQE6
      UniProtKB/TrEMBL
      Q80YA4
      Related
      ENSMUSP00000030628.8, ENSMUST00000030628.15
      Conserved Domains (3) summary
      TIGR03462
      Location:29 → 113
      CarR_dom_SF; lycopene cyclase domain
      pfam09726
      Location:2 → 662
      Macoilin; Transmembrane protein
      pfam16331
      Location:386 → 462
      TolA_bind_tri; TolA binding protein trimerization

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      134530070..134581242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164305.1 → XP_036020198.1  macoilin isoform X2

      Conserved Domains (1) summary
      pfam09726
      Location:1 → 238
      Macoilin; Macoilin family

    2. XM_006539100.4 → XP_006539163.1  macoilin isoform X1

      Conserved Domains (1) summary
      pfam09726
      Location:2 → 384
      Macoilin; Macoilin family

    RNA

    1. XR_004941943.1 RNA Sequence

    2. XR_001784176.2 RNA Sequence

    3. XR_004941944.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TQE6.1 GenPept UniProtKB/Swiss-Prot:Q7TQE6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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