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    Copz1 COPI coat complex subunit zeta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315345, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Copz1provided by RGD
    Official Full Name
    COPI coat complex subunit zeta 1provided by RGD
    Primary source
    RGD:1306154
    See related
    Ensembl:ENSRNOG00000036835 AllianceGenome:RGD:1306154
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in intra-Golgi vesicle-mediated transport; intracellular protein transport; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within toxin transport. Predicted to be located in Golgi membrane. Predicted to be part of COPI vesicle coat. Orthologous to human COPZ1 (COPI coat complex subunit zeta 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 373.8), Liver (RPKM 306.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (136287696..136314131)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (134409523..134435661)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144900050..144926299)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene chromobox 5 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 Neighboring gene nuclear factor, erythroid 2 Neighboring gene microRNA 148b Neighboring gene G protein-coupled receptor 84 Neighboring gene zinc finger protein 385A Neighboring gene uncharacterized LOC134479585

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential localization of coatomer complex isoforms within the Golgi apparatus. Moelleken J, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360540
    2. Identification and characterization of novel isoforms of COP I subunits. Futatsumori M, et al. J Biochem, 2000 Nov. PMID 11056392
    3. Novel isotypic gamma/zeta subunits reveal three coatomer complexes in mammals. Wegmann D, et al. Mol Cell Biol, 2004 Feb. PMID 14729954, Free PMC Article
    4. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Slater LH, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716698, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of differential localization of coatomer complex isoforms within the Golgi apparatus
      Title: Differential localization of coatomer complex isoforms within the Golgi apparatus.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coatomer subunit zeta-1
    Names
    coatomer protein complex, subunit zeta 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108117.1 → NP_001101587.1  coatomer subunit zeta-1

      See identical proteins and their annotated locations for NP_001101587.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474035
      UniProtKB/TrEMBL
      A0A8I5ZKX4, A0A8I6GK73, A6KD05
      Related
      ENSRNOP00000092493.1, ENSRNOT00000100400.1
      Conserved Domains (1) summary
      cd14829
      Location:14 → 145
      Zeta-COP; zeta subunit of the F-COPI complex

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      136287696..136314131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594903.3 → XP_017450392.1  coatomer subunit zeta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GES6, D4A8T3
      Related
      ENSRNOP00000086292.1
      Conserved Domains (1) summary
      cd14829
      Location:14 → 145
      Zeta-COP; zeta subunit of the F-COPI complex

    2. XM_039079350.2 → XP_038935278.1  coatomer subunit zeta-1 isoform X2

      Conserved Domains (1) summary
      cl38905
      Location:14 → 87
      longin-like; Longin-like domains

    3. XM_039079351.2 → XP_038935279.1  coatomer subunit zeta-1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AMR7
      Related
      ENSRNOP00000094720.1
      Conserved Domains (1) summary
      cl38905
      Location:14 → 87
      longin-like; Longin-like domains

    RNA

    1. XR_010052988.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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