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    TEX38 testis expressed 38 [ Homo sapiens (human) ]

    Gene ID: 374973, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TEX38provided by HGNC
    Official Full Name
    testis expressed 38provided by HGNC
    Primary source
    HGNC:HGNC:29589
    See related
    Ensembl:ENSG00000186118 AllianceGenome:HGNC:29589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    THEG4; C1orf223; ATPAF1-AS1
    Summary
    Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 65.6) See more
    Orthologs
    mouse all
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    Genomic context

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    See TEX38 in Genome Data Viewer
    Location:
    1p33
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (46668886..46673594)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (46546126..46550834)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47137526..47139266)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378697 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47131482-47132011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47132012-47132540 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:47133653-47133823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1007 Neighboring gene EFCAB14 antisense RNA 1 Neighboring gene neudesin neurotrophic factor pseudogene 1 Neighboring gene uncharacterized LOC105378698 Neighboring gene EF-hand calcium binding domain 14 Neighboring gene Sharpr-MPRA regulatory region 7632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 851 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:47193413-47194254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:47194255-47195096 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:47210608-47210835 Neighboring gene uncharacterized LOC105378699

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Image-based genome-wide siRNA screen identifies selective autophagy factors. Orvedahl A, et al. Nature, 2011 Dec 1. PMID 22020285, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    testis-expressed protein 38
    Names
    ATPAF1 antisense RNA 1
    ATPAF1 antisense gene protein 1
    testis highly expressed protein 4
    testis-expressed sequence 38 protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145474.4 → NP_001138946.1  testis-expressed protein 38 isoform 1

      See identical proteins and their annotated locations for NP_001138946.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI828862, BC067853, BC126318
      Consensus CDS
      CCDS57999.1
      UniProtKB/Swiss-Prot
      A1A4F8, Q6PEX7
      UniProtKB/TrEMBL
      C9W8M6
      Related
      ENSP00000455854.1, ENST00000334122.5
      Conserved Domains (1) summary
      pfam15834
      Location:13 → 205
      THEG4; Testis highly expressed protein 4

    2. NM_001300863.2 → NP_001287792.1  testis-expressed protein 38 isoform 2

      See identical proteins and their annotated locations for NP_001287792.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AI828862, BC067853, BC144026
      Consensus CDS
      CCDS72780.1
      UniProtKB/TrEMBL
      B7ZLT1
      Related
      ENSP00000456524.1, ENST00000564373.1
      Conserved Domains (1) summary
      pfam15834
      Location:1 → 151
      THEG4; Testis highly expressed protein 4

    3. NM_001300864.2 → NP_001287793.1  testis-expressed protein 38 isoform 3

      See identical proteins and their annotated locations for NP_001287793.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AI828862, BC067853, BC144027
      Consensus CDS
      CCDS72781.1
      UniProtKB/TrEMBL
      B7ZLT2
      Related
      ENSP00000456892.1, ENST00000415500.1
      Conserved Domains (1) summary
      pfam15834
      Location:1 → 129
      THEG4; Testis highly expressed protein 4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      46668886..46673594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541421.4 → XP_011539723.1  testis-expressed protein 38 isoform X1

      Conserved Domains (1) summary
      pfam15834
      Location:14 → 206
      THEG4; Testis highly expressed protein 4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      46546126..46550834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336447.1 → XP_054192422.1  testis-expressed protein 38 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PEX7.3 GenPept UniProtKB/Swiss-Prot:Q6PEX7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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