Ppp1r12b protein phosphatase 1, regulatory subunit 12B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp1r12bprovided by RGD
Official Full Name: protein phosphatase 1, regulatory subunit 12Bprovided by RGD
Primary source: RGD:1309287
See related: Ensembl:ENSRNOG00000051440 AllianceGenome:RGD:1309287
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable enzyme inhibitor activity and phosphatase regulator activity. Predicted to be involved in negative regulation of catalytic activity and signal transduction. Predicted to be located in cytoskeleton. Predicted to be active in A band and Z disc. Orthologous to human PPP1R12B (protein phosphatase 1 regulatory subunit 12B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 207.7), Muscle (RPKM 206.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (48751256..48948933, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (46199418..46397108, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (51583603..51784641, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B.
Title: Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF386425 (e-PCR)
- UniSTS:243729

RH138368 (e-PCR)
- UniSTS:220455

AU048021 (e-PCR)
- UniSTS:109951

BF390593 (e-PCR)
- UniSTS:249502

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in A band	IBA Inferred from Biological aspect of Ancestor more info
located_in A band	ISO Inferred from Sequence Orthology more info
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 12B

Names: protein phosphatase 1, regulatory (inhibitor) subunit 12B

NP_001100648.1

EC 3.1.3.53

XP_006249937.1

EC 3.1.3.53

XP_006249938.1

EC 3.1.3.53

XP_006249942.1

EC 3.1.3.53

XP_008767780.1

EC 3.1.3.53

XP_008767783.1

EC 3.1.3.53

XP_017454282.1

EC 3.1.3.53

XP_038946646.1

EC 3.1.3.53

XP_038946647.1

EC 3.1.3.53

XP_038946648.1

EC 3.1.3.53

XP_063128370.1

EC 3.1.3.53

XP_063128371.1

EC 3.1.3.53

XP_063128373.1

EC 3.1.3.53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107178.5 → NP_001100648.1 protein phosphatase 1 regulatory subunit 12B

See identical proteins and their annotated locations for NP_001100648.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8I6A534, A6ICC9, D3ZIC4

Related

ENSRNOP00000069748.1, ENSRNOT00000089068.2

Conserved Domains (5) summary

cd00204
Location:85 → 269

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:65 → 154

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:219 → 269

Ank_4; Ankyrin repeats (many copies)

pfam15898
Location:876 → 982

PRKG1_interact; cGMP-dependent protein kinase interacting domain

sd00045
Location:90 → 121

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

48751256..48948933 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272303.1 → XP_063128373.1 protein phosphatase 1 regulatory subunit 12B isoform X12
XM_006249876.5 → XP_006249938.1 protein phosphatase 1 regulatory subunit 12B isoform X3

UniProtKB/TrEMBL

A0A8I6A534, A0A8I6A6B6

Related

ENSRNOP00000086607.1

Conserved Domains (5) summary

cd00204
Location:85 → 269

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:65 → 154

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:219 → 269

Ank_4; Ankyrin repeats (many copies)

pfam15898
Location:876 → 976

PRKG1_interact; cGMP-dependent protein kinase interacting domain

sd00045
Location:90 → 121

ANK; ANK repeat [structural motif]
XM_008769561.4 → XP_008767783.1 protein phosphatase 1 regulatory subunit 12B isoform X11

UniProtKB/TrEMBL

A0A8I6GIK9

Related

ENSRNOP00000090864.1

Conserved Domains (1) summary

pfam15898
Location:85 → 185

PRKG1_interact; cGMP-dependent protein kinase interacting domain
XM_006249875.4 → XP_006249937.1 protein phosphatase 1 regulatory subunit 12B isoform X1

UniProtKB/TrEMBL

A0A8I6A534

Related

ENSRNOP00000087080.1, ENSRNOT00000100540.1

Conserved Domains (5) summary

cd00204
Location:85 → 269

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:65 → 154

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:219 → 269

Ank_4; Ankyrin repeats (many copies)

pfam15898
Location:876 → 982

PRKG1_interact; cGMP-dependent protein kinase interacting domain

sd00045
Location:90 → 121

ANK; ANK repeat [structural motif]
XM_039090719.2 → XP_038946647.1 protein phosphatase 1 regulatory subunit 12B isoform X4

UniProtKB/TrEMBL

A0A8I6A534

Conserved Domains (6) summary

PHA03095
Location:61 → 290

PHA03095; ankyrin-like protein; Provisional

PRK07003
Location:530 → 702

PRK07003; DNA polymerase III subunit gamma/tau

sd00045
Location:90 → 121

ANK; ANK repeat [structural motif]

pfam12796
Location:65 → 154

Ank_2; Ankyrin repeats (3 copies)

pfam15898
Location:834 → 940

PRKG1_interact; cGMP-dependent protein kinase interacting domain

cl40436
Location:567 → 619

IPD_PPP1R12; inhibitory phosphorylation domain of protein phosphatase 1 regulatory subunit 12 (PPP1R12) family
XM_006249880.5 → XP_006249942.1 protein phosphatase 1 regulatory subunit 12B isoform X8

See identical proteins and their annotated locations for XP_006249942.1

UniProtKB/TrEMBL

A0A8I6A534

Conserved Domains (4) summary

cd00204
Location:47 → 133

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam13637
Location:51 → 101

Ank_4; Ankyrin repeats (many copies)

pfam15898
Location:708 → 814

PRKG1_interact; cGMP-dependent protein kinase interacting domain

sd00045
Location:48 → 79

ANK; ANK repeat [structural motif]
XM_063272301.1 → XP_063128371.1 protein phosphatase 1 regulatory subunit 12B isoform X10
XM_039090718.2 → XP_038946646.1 protein phosphatase 1 regulatory subunit 12B isoform X2

UniProtKB/TrEMBL

A0A8I6A534

Conserved Domains (6) summary

PHA03095
Location:61 → 290

PHA03095; ankyrin-like protein; Provisional

PHA03369
Location:499 → 786

PHA03369; capsid maturational protease; Provisional

sd00045
Location:90 → 121

ANK; ANK repeat [structural motif]

pfam12796
Location:65 → 154

Ank_2; Ankyrin repeats (3 copies)

pfam15898
Location:876 → 951

PRKG1_interact; cGMP-dependent protein kinase interacting domain

cl40436
Location:609 → 661

IPD_PPP1R12; inhibitory phosphorylation domain of protein phosphatase 1 regulatory subunit 12 (PPP1R12) family
XM_017598793.3 → XP_017454282.1 protein phosphatase 1 regulatory subunit 12B isoform X6

UniProtKB/TrEMBL

A0A8I6A534
XM_039090720.2 → XP_038946648.1 protein phosphatase 1 regulatory subunit 12B isoform X7

UniProtKB/TrEMBL

A0A8I6A534

Conserved Domains (5) summary

PHA03095
Location:61 → 290

PHA03095; ankyrin-like protein; Provisional

PHA03369
Location:499 → 786

PHA03369; capsid maturational protease; Provisional

sd00045
Location:90 → 121

ANK; ANK repeat [structural motif]

pfam12796
Location:65 → 154

Ank_2; Ankyrin repeats (3 copies)

cd21944
Location:606 → 662

IPD_MYPT1; inhibitory phosphorylation domain of myosin phosphatase targeting subunit 1(MYPT1)
XM_063272300.1 → XP_063128370.1 protein phosphatase 1 regulatory subunit 12B isoform X5
XM_008769558.4 → XP_008767780.1 protein phosphatase 1 regulatory subunit 12B isoform X9

See identical proteins and their annotated locations for XP_008767780.1

Conserved Domains (4) summary

cd00204
Location:85 → 269

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:65 → 154

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:219 → 269

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:90 → 121

ANK; ANK repeat [structural motif]