U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ACTN2 actinin alpha 2 [ Gallus gallus (chicken) ]

    Gene ID: 396263, updated on 3-Apr-2024

    Summary

    Go to the top of the page Help
    Symbol
    ACTN2provided by CGNC
    Full Name
    actinin alpha 2provided by CGNC
    Primary source
    CGNC:10755
    See related
    Ensembl:ENSGALG00010009118
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ACTN2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (37299184..37376089, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (37203541..37280288, complement)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121110428 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase Neighboring gene uncharacterized LOC121110429 Neighboring gene HEAT repeat containing 1 Neighboring gene galectin 8 Neighboring gene EDAR associated death domain

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A chick skeletal-muscle alpha-actinin gene gives rise to two alternatively spliced isoforms which differ in the EF-hand Ca(2+)-binding domain. Parr T, et al. Eur J Biochem, 1992 Dec 15. PMID 1483465
    2. Primary structure of chicken skeletal muscle and fibroblast alpha-actinins deduced from cDNA sequences. Arimura C, et al. Eur J Biochem, 1988 Nov 15. PMID 3197725
    3. Transfection of chicken skeletal muscle alpha-actinin cDNA into nonmuscle and myogenic cells: dimerization is not essential for alpha-actinin to bind to microfilaments. Tokuue Y, et al. Exp Cell Res, 1991 Dec. PMID 1720388
    4. Functional role of alpha-actinin, PI 3-kinase and MEK1/2 in insulin-like growth factor I receptor kinase regulated motility of human breast carcinoma cells. Guvakova MA, et al. J Cell Sci, 2002 Nov 1. PMID 12356918
    5. An interaction between zyxin and alpha-actinin. Crawford AW, et al. J Cell Biol, 1992 Mar. PMID 1541635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in muscle cell development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    alpha-actinin-2
    Names
    F-actin cross-linking protein
    alpha-actinin skeletal muscle

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205323.2 → NP_990654.1  alpha-actinin-2

      See identical proteins and their annotated locations for NP_990654.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000063
      UniProtKB/Swiss-Prot
      P20111, Q90821
      UniProtKB/TrEMBL
      A0A8V0XVZ5
      Related
      ENSGALP00010012437.1, ENSGALT00010021756.1
      Conserved Domains (6) summary
      COG5126
      Location:753 → 897
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00176
      Location:405 → 632
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:284 → 394
      Spectrin; Spectrin repeat
      pfam08726
      Location:827 → 893
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cd21214
      Location:38 → 142
      CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
      cd21216
      Location:146 → 260
      CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      37299184..37376089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046938534.1 → XP_046794490.1  alpha-actinin-2 isoform X1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      37203541..37280288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046913235.1 → XP_046769191.1  alpha-actinin-2 isoform X1

    2. XM_046913234.1 → XP_046769190.1  alpha-actinin-2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20111.1 GenPept UniProtKB/Swiss-Prot:P20111

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.