ing-3 Inhibitor of growth protein [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: ing-3
Gene description: Inhibitor of growth protein
Primary source: WormBase:WBGene00013095
Locus tag: CELE_Y51H1A.4
See related: AllianceGenome:WB:WBGene00013095
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable methylated histone binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of NuA4 histone acetyltransferase complex. Is expressed in several structures, including hypodermis; intestine; pharynx; spermatheca; and vulva. Used to study cancer. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma and squamous cell carcinoma. Orthologous to several human genes including ING3 (inhibitor of growth family member 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ing-3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (13876034..13882585)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Both ing-3(RNAi) and ing-3 mutant strains demonstrate that the gene likely functions in concert with the p53 homolog, cep-1, to induce germ-cell apoptosis in response to ionizing radiation.
Title: The Caenorhabditis elegans ing-3 gene regulates ionizing radiation-induced germ-cell apoptosis in a p53-associated pathway.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y51H1A.4 (e-PCR)
- UniSTS:319779

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Inhibitor of growth protein

NP_496909.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

13876034..13882585

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064508.5 → NP_496909.1 Inhibitor of growth protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496909.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XWJ8

Conserved Domains (2) summary

cd15505
Location:430 → 474

PHD_ING; PHD finger found in the inhibitor of growth (ING) protein family

pfam12998
Location:3 → 101

ING; Inhibitor of growth proteins N-terminal histone-binding