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    bus-4 N-acetylgalactosaminide beta-1,3-galactosyltransferase [ Caenorhabditis elegans ]

    Gene ID: 188726, updated on 23-May-2024

    Summary

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    Gene symbol
    bus-4
    Gene description
    N-acetylgalactosaminide beta-1,3-galactosyltransferase
    Primary source
    WormBase:WBGene00044620
    Locus tag
    CELE_T22B11.2
    See related
    AllianceGenome:WB:WBGene00044620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be involved in O-glycan processing, core 1. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in intestine; pharynx; and seam cell. Human ortholog(s) of this gene implicated in Tn polyagglutination syndrome. Orthologous to human C1GALT1C1 (C1GALT1 specific chaperone 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See bus-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (4688269..4691936)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene AMOP domain-containing protein Neighboring gene 2-oxoglutarate dehydrogenase, mitochondrial;Transketolase-like pyrimidine-binding domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans bacterial pathogen resistant bus-4 mutants produce altered mucins. Parsons LM, et al. PLoS One, 2014. PMID 25296196, Free PMC Article
    2. The hmsHFRS operon of Xenorhabdus nematophila is required for biofilm attachment to Caenorhabditis elegans. Drace K, et al. Appl Environ Microbiol, 2008 Jul. PMID 18515487, Free PMC Article
    3. Pmr-1 gene affects susceptibility of Caenorhabditis elegans to Staphylococcus aureus infection through glycosylation and stress response pathways' alterations. Schifano E, et al. Virulence, 2019 Dec. PMID 31771413, Free PMC Article
    4. Caenorhabditis elegans mutants resistant to attachment of Yersinia biofilms. Darby C, et al. Genetics, 2007 May. PMID 17339204, Free PMC Article
    5. Glycosylation genes expressed in seam cells determine complex surface properties and bacterial adhesion to the cuticle of Caenorhabditis elegans. Gravato-Nobre MJ, et al. Genetics, 2011 Jan. PMID 20980242, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in O-glycan processing, core 1 IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylgalactosaminide beta-1,3-galactosyltransferase
    NP_500615.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4688269..4691936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068214.3 → NP_500615.2  N-acetylgalactosaminide beta-1,3-galactosyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500615.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44563
      Conserved Domains (1) summary
      cl21608
      Location:104 → 235
      Galactosyl_T; Galactosyltransferase
    Nucleotide Protein
    Heading Accession and Version

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