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    mcm7 minichromosome maintenance complex component 7 [ Danio rerio (zebrafish) ]

    Gene ID: 192333, updated on 19-May-2024

    Summary

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    Official Symbol
    mcm7provided by ZNC
    Official Full Name
    minichromosome maintenance complex component 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020419-27
    See related
    AllianceGenome:ZFIN:ZDB-GENE-020419-27
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    nyz175; chunp6911; sr:nyz175
    Summary
    Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Acts upstream of or within regulation of cilium assembly. Predicted to be part of MCM complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MCM7 (minichromosome maintenance complex component 7). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: suggests misassembly
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See mcm7 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (93967..102282)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (150202..158517)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene cohesin subunit SA-2-like Neighboring gene actinodin4 Neighboring gene microRNA 19d Neighboring gene microRNA 93 Neighboring gene microRNA 25 Neighboring gene glypican 2 Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dose- and time-dependent expression patterns of zebrafish orthologs of selected E2F target genes in response to serum starvation/replenishment. Sucularli C, et al. Mol Biol Rep, 2011 Aug. PMID 21116857
    2. Evolutionary diversification of MCM3 genes in Xenopus laevis and Danio rerio. Shinya M, et al. Cell Cycle, 2014. PMID 25485507, Free PMC Article
    3. Resting cells rely on the DNA helicase component MCM2 to build cilia. Casar Tena T, et al. Nucleic Acids Res, 2019 Jan 10. PMID 30329080, Free PMC Article
    4. Scratch2 prevents cell cycle re-entry by repressing miR-25 in postmitotic primary neurons. Rodríguez-Aznar E, et al. J Neurosci, 2013 Mar 20. PMID 23516276, Free PMC Article
    5. DHX33 Transcriptionally Controls Genes Involved in the Cell Cycle. Yuan B, et al. Mol Cell Biol, 2016 Dec 1. PMID 27601587, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA strand elongation involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MCM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA replication licensing factor MCM7
    Names
    MCM7 minichromosome maintenance deficient 7
    NP_997734.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212569.1 → NP_997734.1  DNA replication licensing factor MCM7

      See identical proteins and their annotated locations for NP_997734.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045497
      UniProtKB/TrEMBL
      Q7ZVL6
      Conserved Domains (2) summary
      pfam14551
      Location:14 → 93
      MCM_N; MCM N-terminal domain
      cl25443
      Location:145 → 641
      MCM_OB; MCM OB domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      93967..102282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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