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    plscr3b phospholipid scramblase 3b [ Danio rerio (zebrafish) ]

    Gene ID: 405802, updated on 27-Mar-2024

    Summary

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    Official Symbol
    plscr3bprovided by ZNC
    Official Full Name
    phospholipid scramblase 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2517
    See related
    Ensembl:ENSDARG00000069432 AllianceGenome:ZFIN:ZDB-GENE-040426-2517
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:77051
    Summary
    Predicted to enable phospholipid scramblase activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to be active in plasma membrane. Is expressed in several structures, including blastomere; ectoderm; epidermis; intermediate cell mass of mesoderm; and nervous system. Orthologous to several human genes including PLSCR2 (phospholipid scramblase 2) and PLSCR3 (phospholipid scramblase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See plscr3b in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (26581644..26603470, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (26311163..26332277, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene tyrosine kinase, non-receptor, 1 Neighboring gene si:dkey-62k3.6 Neighboring gene PHD finger protein 23b Neighboring gene heat shock factor binding protein 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Analyses of mRNA structure dynamics identify embryonic gene regulatory programs. Beaudoin JD, et al. Nat Struct Mol Biol, 2018 Aug. PMID 30061596, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC77051

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables phospholipid scramblase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid scramblase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in plasma membrane phospholipid scrambling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within plasma membrane phospholipid scrambling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid scramblase 1; phospholipid scramblase 3b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212866.1 → NP_998031.1  phospholipid scramblase 3b

      See identical proteins and their annotated locations for NP_998031.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066765
      UniProtKB/TrEMBL
      A0A8M1PFW8, Q6NY24
      Related
      ENSDARP00000089774.3, ENSDART00000099003.6
      Conserved Domains (2) summary
      pfam03803
      Location:80 → 302
      Scramblase; Scramblase
      cl25887
      Location:4 → 94
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      26581644..26603470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021477454.1 → XP_021333129.1  phospholipid scramblase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M1PFW8, Q6NY24
      Related
      ENSDARP00000153626.1, ENSDART00000188934.1
      Conserved Domains (2) summary
      pfam03803
      Location:80 → 302
      Scramblase; Scramblase
      cl25887
      Location:4 → 94
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    2. XM_021477455.1 → XP_021333130.1  phospholipid scramblase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QGS0
      Conserved Domains (2) summary
      pfam03803
      Location:65 → 287
      Scramblase
      pfam12526
      Location:4 → 76
      DUF3729; Protein of unknown function (DUF3729)
    Nucleotide Protein
    Heading Accession and Version

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