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    zfp36l2 zinc finger protein 36, C3H type-like 2 [ Danio rerio (zebrafish) ]

    Gene ID: 333941, updated on 31-Mar-2024

    Summary

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    Official Symbol
    zfp36l2provided by ZNC
    Official Full Name
    zinc finger protein 36, C3H type-like 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5873
    See related
    Ensembl:ENSDARG00000021806 AllianceGenome:ZFIN:ZDB-GENE-030131-5873
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi22c11; zgc:76924; wu:fi22c11
    Summary
    Predicted to enable metal ion binding activity. Predicted to be located in cytoplasm. Orthologous to human ZFP36L2 (ZFP36 ring finger protein like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (25376639..25380015, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (25285279..25288655, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene hydroxycarboxylic acid receptor 1-4 Neighboring gene transfer RNA isoleucine (anticodon UAU) Neighboring gene uncharacterized LOC103911923 Neighboring gene uncharacterized LOC103911924

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zfp36l1b protects angiogenesis through Notch1b/Dll4 and Vegfa regulation in zebrafish. Hu YX, et al. Atherosclerosis, 2020 Sep. PMID 32882641
    2. Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders. Gómez-Marín C, et al. Proc Natl Acad Sci U S A, 2015 Jun 16. PMID 26034287, Free PMC Article
    3. Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Moore C, et al. Blood Adv, 2018 Oct 23. PMID 30309860, Free PMC Article
    4. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
    5. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes.
      Title: Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables mRNA 3'-UTR AU-rich region binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mRNA decay activator protein ZFP36L2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207055.1 → NP_996938.1  mRNA decay activator protein ZFP36L2

      See identical proteins and their annotated locations for NP_996938.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066478
      UniProtKB/TrEMBL
      Q6NYS5
      Conserved Domains (2) summary
      pfam00642
      Location:55 → 80
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam04553
      Location:11 → 36
      Tis11B_N; Tis11B like protein, N terminus

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      25376639..25380015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156270.3 → XP_005156327.1  mRNA decay activator protein ZFP36L2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B342, F1QU82
      Related
      ENSDARP00000113845.1, ENSDART00000142674.2
      Conserved Domains (2) summary
      pfam00642
      Location:118 → 143
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam04553
      Location:3 → 99
      Tis11B_N; Tis11B like protein, N terminus

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394845.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      253627..256977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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