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    si:dkey-46g23.5 si:dkey-46g23.5 [ Danio rerio (zebrafish) ]

    Gene ID: 562067, updated on 27-Mar-2024

    Summary

    Official Symbol
    si:dkey-46g23.5provided by ZNC
    Official Full Name
    si:dkey-46g23.5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9306
    See related
    Ensembl:ENSDARG00000008835 AllianceGenome:ZFIN:ZDB-GENE-030131-9306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa56g11; wu:fa56g11
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See si:dkey-46g23.5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (3432960..3448095, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (3650707..3665842, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene zgc:171446 Neighboring gene zgc:171445 Neighboring gene zgc:165453 Neighboring gene zgc:171426

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    uncharacterized protein LOC562067
    Names
    alpha-2-macroglobulin-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201405.2NP_001188334.2  uncharacterized protein LOC562067 precursor

      Status: VALIDATED

      Source sequence(s)
      BC152015, BX322654, CABZ01040995, CD594314
      UniProtKB/TrEMBL
      A0A8M1NYK0, F1QS86
      Related
      ENSDARP00000073345.6, ENSDART00000078886.6
      Conserved Domains (6) summary
      cd02897
      Location:9941269
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:776864
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:170261
      A2M_N; MG2 domain
      pfam07677
      Location:13881477
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:10461269
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:506650
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      3432960..3448095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)