pola2 polymerase (DNA directed), alpha 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pola2provided by ZNC
Official Full Name: polymerase (DNA directed), alpha 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-778
See related: Ensembl:ENSDARG00000015070 AllianceGenome:ZFIN:ZDB-GENE-030131-778
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56124; zgc:77841; wu:fb48f05
Summary: Predicted to enable DNA binding activity. Acts upstream of or within with a positive effect on cell population proliferation and fin regeneration. Predicted to be located in nucleus. Predicted to be part of alpha DNA polymerase:primase complex. Orthologous to human POLA2 (DNA polymerase alpha 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (17174795..17184516, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (17139083..17148804, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb48f05.x1 (e-PCR)
- UniSTS:190602

fc51f02.y1 (e-PCR)
- UniSTS:194037

AI497520 (e-PCR)
- UniSTS:206332

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_positive_effect cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of alpha DNA polymerase:primase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA polymerase alpha subunit B

Names: polymerase (DNA-directed), alpha (70kD)

NP_955875.2

EC 2.7.7.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199581.2 → NP_955875.2 DNA polymerase alpha subunit B

Status: VALIDATED

Source sequence(s)

BC065460, BX465215, EH494906, EH521232, EH582754, EH606241

UniProtKB/TrEMBL

A0A8M1PBJ8, B0S687, Q6P0S9

Related

ENSDARP00000002618.6, ENSDART00000025803.7

Conserved Domains (2) summary

pfam04042
Location:346 → 550

DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B

pfam08418
Location:23 → 246

Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal